Description

3-Fluoro-5-Iodotoluene is a valuable halogenated aromatic building block, specifically engineered for advanced organic synthesis. This compound matters for its unique substitution pattern, offering precise regiochemical control in cross-coupling reactions and functional group transformations. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring fluorinated and iodinated aromatic motifs for enhanced bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and pesticides, where the fluorine and iodine atoms contribute to biological activity and environmental persistence profiles.
• Material Science Research: Serves as a monomer or functionalization agent in the creation of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions such as Suzuki, Sonogashira, and Heck couplings, enabling the construction of complex biaryl and conjugated systems.
• Chemical Biology & Diagnostics: Employed in the synthesis of molecular probes, radioligands, and fluorescent tags for imaging and diagnostic applications.
• Organic Synthesis Building Block: Utilized in nucleophilic substitution, halogen exchange, and directed ortho-metalation reactions to introduce further functionality.

Basic Information

Product Name	3-Fluoro-5-Iodotoluene
CAS No.	491862-84-1
Molecular Formula	C7H6FI
Molecular Weight	236.03 g/mol
Synonyms	1-Fluoro-3-iodo-5-methylbenzene; 3-Fluoro-5-iodotoluene; 5-Iodo-3-fluorotoluene; 3-Fluoro-5-methyl-1-iodobenzene; 3-Fluoro-5-iodo-1-methylbenzene; Toluene, 3-fluoro-5-iodo-; 3-Fluoro-5-iodo toluene
EINECS	Contact for details

Quality Control

Our 3-Fluoro-5-Iodotoluene is produced under strict quality management protocols. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing purity, impurity profiles, and physical data. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible materials such as strong bases and oxidizing agents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Melting Point	Contact for details
Heavy Metals	<10 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.