Description

Diethyl 2-(2,6-Difluorophenyl)Malonate is a high-purity fluorinated malonate ester, serving as a critical synthetic intermediate in advanced organic chemistry. Its value lies in providing a versatile building block for constructing complex molecules containing a difluorophenyl moiety, a key pharmacophore in modern drug discovery. This compound is essential for research and development chemists in the pharmaceutical and agrochemical industries, where it is used to synthesize active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly those targeting central nervous system (CNS) disorders, inflammation, and oncology.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the difluorophenyl group enhances biological activity and environmental stability.
• Material Science Precursor: Serves as a monomer or modifier in the synthesis of specialty polymers and advanced materials with tailored properties.
• Ligand and Catalyst Development: Employed in the preparation of novel ligands for asymmetric catalysis and metal-organic frameworks (MOFs).
• Fluorine Chemistry Research: A valuable reagent for academic and industrial research exploring the effects of fluorine substitution on molecular properties and reactivity.
• Custom Synthesis and Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of bespoke compounds and development candidates.

Basic Information

Product Name	Diethyl 2-(2,6-Difluorophenyl)Malonate
CAS No.	491860-05-0
Molecular Formula	C₁₃H₁₄F₂O₄
Molecular Weight	272.25 g/mol
Synonyms	Diethyl (2,6-Difluorophenyl)malonate; 2,6-Difluorophenylmalonic Acid Diethyl Ester; Diethyl (2,6-Difluorobenzyl)malonate; Propanedioic acid, 2-(2,6-difluorophenyl)-, diethyl ester; Diethyl 2-(2,6-Difluorophenyl)propanedioate; (2,6-Difluorophenyl)malonic Acid Diethyl Ester; Diethyl (2,6-Difluorophenyl)propanedioate; 491860-05-0
EINECS	Contact for details

Quality Control

Our Diethyl 2-(2,6-Difluorophenyl)Malonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specifications and test results. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container must be kept tightly closed to prevent moisture absorption and potential degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.