Description

3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine is a high-value heterocyclic building block featuring a fused triazolopyrazine core substituted with a trifluoromethyl group. This compound matters for its role as a key synthetic intermediate in the development of advanced pharmaceuticals and agrochemicals, where the CF3 group is prized for its ability to modulate lipophilicity, metabolic stability, and bioavailability. It is primarily needed by research chemists and process development scientists in pharmaceutical R&D, agrochemical discovery, and material science for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: Serves as a critical scaffold in the synthesis of potential drug candidates, particularly for central nervous system (CNS) targets, kinase inhibitors, and anti-infective agents.
• Agrochemical Research: Used in the development of new-generation herbicides, fungicides, and insecticides, leveraging the biological activity enhancement provided by the trifluoromethyl group.
• Material Science Precursor: Acts as a building block for creating specialty polymers, ligands for catalysis, and organic electronic materials due to its unique electronic properties.
• Chemical Biology Probe: Employed in the design and synthesis of molecular probes and tags for studying biological pathways and protein interactions.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific custom synthesis projects requiring this specialized heterocycle.

Basic Information

Product Name	3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine
CAS No.	486460-20-2
Molecular Formula	C6H3F3N4
Molecular Weight	188.11 g/mol
Synonyms	3-(Trifluoromethyl)-[1,2,4]triazolo[4,3-a]pyrazine; 1,2,4-Triazolo[4,3-a]pyrazine, 3-(trifluoromethyl)-; 3-Trifluoromethyl-1,2,4-triazolo[4,3-a]pyrazine; 3-(Trifluoromethyl)-1,2,4-triazolopyrazine; 486460-20-2; 3-CF3-1,2,4-triazolo[4,3-a]pyrazine
EINECS	Contact for details

Quality Control

Our 3-(Trifluoromethyl)-1,2,4-Triazolo[4,3-A]Pyrazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for advanced pharmaceutical intermediates, ensuring reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Keep away from incompatible materials. For long-term storage, consider storing under an inert atmosphere to maintain optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.