Description

Geldanamycin, 17-[(6-Aminohexyl)Amino]-17-Demethoxy- is a chemically modified derivative of the natural ansamycin antibiotic geldanamycin, designed to enhance its pharmacological properties and utility in research. This compound is a critical tool for studying the Hsp90 molecular chaperone system, a key target in oncology and neurodegenerative disease research. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and molecular biology.

Application

• Biochemical Research: As a potent and specific inhibitor of Hsp90, used to study protein folding, client protein degradation, and chaperone-mediated signaling pathways.
• Anticancer Agent Development: Serves as a lead compound and reference standard in the discovery and validation of novel Hsp90-targeted therapeutics for various cancers.
• Neurodegenerative Disease Models: Used in research models to investigate the role of Hsp90 in tauopathy, α-synuclein aggregation, and other protein misfolding diseases.
• Proteostasis Studies: A key reagent for exploring cellular mechanisms of proteostasis, heat shock response, and protein quality control.
• Chemical Biology Probes: The aminohexyl side chain facilitates conjugation, making it suitable for creating affinity resins, fluorescent probes, or biotinylated derivatives for pull-down assays.
• Reference Standard: Used in analytical laboratories for method development, quality control, and quantification in pharmacokinetic and metabolic studies.

Basic Information

Item	Details
Product Name	Geldanamycin, 17-[(6-Aminohexyl)Amino]-17-Demethoxy-
CAS No.	485395-71-9
Molecular Formula	C34H48N4O7
Molecular Weight	624.77 g/mol
Synonyms	17-AAG (6-Aminohexylamino analog); 17-Demethoxy-17-[(6-aminohexyl)amino]geldanamycin; 6-AHA-GA; 17-(6-Aminohexylamino)-17-demethoxygeldanamycin; Ansamycin Hsp90 Inhibitor derivative; 17-AG (Aminohexyl); Hsp90 Inhibitor, Geldanamycin derivative
EINECS	Contact for details

Quality Control

Our Geldanamycin, 17-[(6-Aminohexyl)Amino]-17-Demethoxy- is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, mass spectrometry for structural confirmation, and NMR for identity verification. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade standards. Specifications can be tailored to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated under an inert atmosphere. Allow the vial to warm to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.