Description

3-Chloro-5-Fluorophenylmagnesium Bromide is a highly reactive organometallic reagent, specifically a Grignard reagent, essential for forming new carbon-carbon bonds in complex organic syntheses. Its value lies in its ability to introduce the versatile 3-chloro-5-fluorophenyl moiety into target molecules, a key structural motif in advanced chemical development. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials industries for constructing active pharmaceutical ingredients (APIs), crop protection agents, and specialty chemical intermediates.

Application

• Pharmaceutical Intermediate Synthesis: A critical building block for the preparation of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Development: Used in the synthesis of advanced herbicides, fungicides, and insecticides where the chloro-fluorophenyl group enhances biological activity and stability.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science Research: Employed in the synthesis of monomers and functionalized aromatics for advanced polymers, liquid crystals, and organic electronic materials.
• Custom Chemical and Contract Manufacturing: A key reagent for custom synthesis and scale-up services for clients requiring specific fluorinated and chlorinated aromatic structures.
• Academic and Industrial R&D: Fundamental reagent for methodological development in organic chemistry and for exploring new reaction pathways.

Basic Information

Product Name	3-Chloro-5-Fluorophenylmagnesium Bromide
CAS No.	480438-50-4
Molecular Formula	C6H3BrClFMg
Molecular Weight	233.74 g/mol
Synonyms	(3-Chloro-5-fluorophenyl)magnesium bromide; Magnesium, bromo(3-chloro-5-fluorophenyl)-; 3-Chloro-5-fluoro-1-bromomagnesio-benzene; 3-Chloro-5-fluorophenyl Grignard reagent; 3-Chloro-5-fluorobenzene magnesium bromide; 1-Bromo-3-chloro-5-fluorobenzene magnesium; 3-Chloro-5-fluorophenylmagnesium bromide solution; 3-Cl-5-F-C6H3MgBr
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-Fluorophenylmagnesium Bromide is manufactured under strict quality management systems to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Each lot undergoes rigorous analytical testing, including titration for active Grignard concentration and GC analysis to confirm solvent composition and by-product levels. Certificates of Analysis (COA) detailing concentration, purity, and solvent specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. This material is highly reactive, hygroscopic (moisture-sensitive), and typically supplied as a solution in ether solvents like THF or diethyl ether, which are highly volatile. Store under a dry inert atmosphere (argon or nitrogen) at recommended temperatures of 2°C to 8°C to maintain stability and prevent concentration drift. Keep away from heat, sparks, open flames, and any sources of moisture or protic solvents.

Specification

Item	Specification
Appearance	Clear, colorless to light brown solution
Concentration	0.5 M to 2.0 M in specified solvent (typically THF)
Assay (by Titration)	≥ 95% of stated concentration
Solvent	Specified anhydrous ether (THF, Diethyl ether, 2-MeTHF)
Identification (IR/NMR)	Conforms to structure
Water Content (Karl Fischer)	< 100 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.