Description

(2-(4-Morpholinylmethyl)Phenyl)Magnesium Bromide is a highly reactive organometallic Grignard reagent, specifically an aryl magnesium bromide derivative. This compound is valued for its role as a versatile building block in advanced organic synthesis, enabling the formation of new carbon-carbon bonds. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for the synthesis of complex molecules and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for constructing complex molecular scaffolds in the development of new drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Research: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring specific aryl-morpholine motifs.
• Material Science: Serves as a precursor for creating functionalized organic materials, including ligands for catalysts and monomers for advanced polymers.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions such as Kumada coupling to introduce the (2-(4-morpholinylmethyl)phenyl) group into target molecules.
• Nucleophilic Addition Reactions: Reacts with a wide range of electrophiles including carbonyl compounds (aldehydes, ketones, esters) and epoxides.
• Academic & Contract Research: A critical tool in academic laboratories and CROs (Contract Research Organizations) for methodological development and exploratory chemistry.

Basic Information

Product Name	(2-(4-Morpholinylmethyl)Phenyl)Magnesium Bromide
CAS No.	480424-77-9
Molecular Formula	C11H14BrMgNO
Molecular Weight	280.44 g/mol
Synonyms	[2-(Morpholin-4-ylmethyl)phenyl]magnesium bromide; 2-(4-Morpholinylmethyl)phenylmagnesium bromide; (2-(Morpholinomethyl)phenyl)magnesium bromide; Magnesium, bromo[2-[(4-morpholinyl)methyl]phenyl]-; Grignard Reagent (2-Morpholinomethylphenyl)magnesium bromide; (2-(N-Morpholinomethyl)phenyl)magnesium bromide
EINECS	Contact for details

Quality Control

Every batch of (2-(4-Morpholinylmethyl)Phenyl)Magnesium Bromide is produced and tested under stringent quality protocols to ensure consistency and reliability for sensitive synthetic applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as concentration, titration assay, and impurity profile. Our quality management system is designed to support cGMP (current Good Manufacturing Practice) requirements for pharmaceutical development.

Storage

Preserve in a tightly closed container, protected from light. This material is highly reactive, hygroscopic (moisture-sensitive), and typically supplied as a solution in tetrahydrofuran (THF) or diethyl ether. Store under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C to 8°C for extended stability. Keep away from heat, sparks, open flames, and oxidizing agents. Use appropriate ventilation and explosion-proof equipment.

Specification

Item	Specification
Appearance (Solution)	Clear, colorless to light yellow or brown
Concentration	0.5 M in THF or Et2O (Typical)
Assay (Titration)	≥ 95%
Identification (IR)	Conforms to structure
Water Content (KF)	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.