Description

Cnqx Disodium Salt is a high-purity, water-soluble salt form of the potent and selective AMPA/kainate receptor antagonist, 6-Cyano-7-nitroquinoxaline-2,3-dione. This compound is a critical research-grade chemical for neuroscience and pharmacology, enabling precise investigation of glutamatergic signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and diagnostic developers for neurobiological studies, receptor characterization, and the development of novel therapeutic agents targeting neurological disorders.

Application

• Neuroscience Research: As a selective non-NMDA glutamate receptor antagonist for studying excitatory synaptic transmission, neuronal excitability, and mechanisms of neuroprotection.
• Pharmacological Screening: Used in high-throughput assays and in vitro models to evaluate drug candidates targeting AMPA and kainate receptors.
• Biochemical Studies: A key tool for investigating the role of glutamate receptors in cellular signaling cascades, synaptic plasticity, and long-term potentiation (LTP).
• Disease Model Development: Essential for creating and validating experimental models of stroke, epilepsy, neurodegenerative diseases, and chronic pain.
• Diagnostic Reagent Manufacturing: Potential use as a reference standard or active component in the development of research kits and diagnostic assays.

Basic Information

Product Name	Cnqx Disodium Salt
CAS No.	479347-85-8
Molecular Formula	C9H2N4Na2O5
Molecular Weight	308.12 g/mol
Synonyms	6-Cyano-7-nitroquinoxaline-2,3-dione disodium salt; CNQX disodium; CNQX-Na2; FG-9041 disodium salt; AMPA/kainate receptor antagonist CNQX disodium; CNQX disodium hydrate (common form); DNQX disodium salt (related compound); Quinoxalinedione CNQX-Na2
EINECS	Contact for details

Quality Control

Our Cnqx Disodium Salt is manufactured under strict quality protocols to ensure batch-to-batch consistency and high chemical purity suitable for sensitive research applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to ISO 9001 quality management principles, and our analytical methods, including HPLC and NMR, are validated to provide reliable specifications for the scientific community.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to minimize exposure to atmospheric humidity. For long-term storage, consider desiccants.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤5.0%
Heavy Metals	<20 ppm
Solubility	Soluble in water, phosphate buffered saline (PBS)
Biological Activity	IC50 for AMPA receptors < 1 µM (typical, cell-based assay)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.