Description

n-trans-Boc-(3S)-Fluoropyrrolidine is a high-purity, chiral fluorinated building block of significant importance in modern synthetic chemistry. This compound is specifically designed for the synthesis of complex molecules where the introduction of a fluorine atom and a protected amine group is critical for modulating biological activity and physicochemical properties. It is an essential intermediate for pharmaceutical researchers and fine chemical manufacturers developing new active pharmaceutical ingredients (APIs), particularly in therapeutic areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, including protease inhibitors and kinase inhibitors.
• Agrochemical Synthesis: Used in creating advanced, fluorine-containing active ingredients for crop protection with enhanced efficacy and environmental profile.
• Peptidomimetics & PROTACs: Serves as a crucial component in the construction of peptide mimics and Proteolysis-Targeting Chimeras (PROTACs) for targeted protein degradation.
• Fluorine-18 Radiochemistry: A potential precursor for the synthesis of positron emission tomography (PET) imaging tracers, leveraging the fluorine atom for labeling.
• Material Science Research: Employed in the synthesis of specialty polymers and liquid crystals where fluorinated pyrrolidine structures impart unique electronic and surface properties.
• Academic & Process Chemistry: A valuable reagent for methodological development in asymmetric synthesis and scale-up process optimization in university and industrial R&D labs.

Basic Information

Product Name	n-trans-Boc-(3S)-Fluoropyrrolidine
CAS No.	479253-00-4
Molecular Formula	C9H16FNO2
Molecular Weight	189.23 g/mol
Synonyms	(3S)-1-[(1,1-Dimethylethoxy)carbonyl]-3-fluoropyrrolidine; tert-Butyl (3S)-3-fluoropyrrolidine-1-carboxylate; (3S)-3-Fluoro-1-Boc-pyrrolidine; (S)-3-Fluoro-1-Boc-pyrrolidine; 1-Boc-(3S)-3-fluoropyrrolidine; (S)-1-N-Boc-3-fluoropyrrolidine; trans-Boc-(3S)-Fluoropyrrolidine; (S)-tert-Butyl 3-fluoropyrrolidine-1-carboxylate
EINECS	Contact for details

Quality Control

Our n-trans-Boc-(3S)-Fluoropyrrolidine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as chiral purity, chemical purity, and identity confirmation. We support development and commercial projects requiring compliance with cGMP and ICH Q7 guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.