Description

Thiosildenafil is a synthetic organic compound belonging to the thio-derivative class of phosphodiesterase type 5 (PDE5) inhibitors. It serves as a crucial pharmaceutical intermediate and research chemical for the development and study of novel therapeutic agents. This high-purity compound is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions focused on urology and cardiovascular pharmacology.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced PDE5 inhibitor analogs and related active pharmaceutical ingredients (APIs).
• Research & Development: Used in preclinical studies to investigate structure-activity relationships (SAR) and metabolic pathways of thio-analog compounds.
• Reference Standard: Serves as an analytical standard for quality control and method development in pharmaceutical analysis using HPLC, LC-MS, or NMR.
• Chemical Synthesis: Employed in organic synthesis for introducing specific thio-functional groups into complex molecular architectures.
• Biochemical Research: Tool compound for in-vitro enzymatic assays to study PDE5 inhibition kinetics and selectivity.

Basic Information

Product Name	Thiosildenafil
CAS No.	479073-79-5
Molecular Formula	C22H30N6O4S
Molecular Weight	474.58 g/mol
Synonyms	Thiosildenafil; 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; PDE5 Inhibitor Thio-analog; Sildenafil Thio-derivative; 479073-79-5; Thio-Sildenafil
EINECS	Contact for details

Quality Control

Our Thiosildenafil is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC purity assay, residual solvent analysis, and identity confirmation (IR, NMR, MS) to ensure it meets exacting standards for research and synthesis. Certificates of Analysis (COA) with complete chromatographic data are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.