Description

R-Dapoxetine CAS NO 119357-36-7 is the R-enantiomer of dapoxetine, a selective serotonin reuptake inhibitor (SSRI) of significant interest in pharmaceutical research and development. This high-purity chiral intermediate is critical for the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and for advanced pharmacological studies. It is primarily required by pharmaceutical R&D laboratories, fine chemical manufacturers, and academic institutions focused on neuropharmacology and the development of novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of enantiomerically pure SSRIs and related compounds.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for method development, validation, and quality control testing.
• Pharmacological Research: Employed in preclinical studies to investigate the specific biological activity, metabolism, and pharmacokinetic profile of the R-enantiomer.
• Process Chemistry Development: Utilized in the development and optimization of asymmetric synthesis routes within fine chemical and API manufacturing.
• Impurity Profiling: Acts as a critical impurity standard for the analysis and control of the stereoisomeric purity of dapoxetine and related substances.

Basic Information

Product Name	R-Dapoxetine
CAS No.	119357-36-7
Molecular Formula	C21H23NO
Molecular Weight	305.41 g/mol
Synonyms	(R)-Dapoxetine; (R)-N,N-Dimethyl-3-(naphthalen-1-yloxy)-1-phenylpropan-1-amine; (R)-Dapoxetine Hydrochloride (salt form); LY 210448 (R-enantiomer); R-(-)-Dapoxetine; (R)-1-[3-(Dimethylamino)propyl]-1-phenyl-3-naphthalen-1-oxypropylamine; (R)-DAP
EINECS	Contact for details

Quality Control

Our R-Dapoxetine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess (ee) determination, identity confirmation by IR and NMR, and precise assay by HPLC to ensure high chemical and stereochemical purity. A Certificate of Analysis (COA) detailing all specifications and test results is provided with every shipment to guarantee traceability and compliance with your research or production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.