Description

Desmethyl Fondenafil is a high-purity pharmaceutical intermediate and reference standard of significant importance in research and development. Its primary value lies in its role as a key structural analog and metabolite in the study of PDE5 inhibitor compounds, enabling precise pharmacological and analytical investigations. This product is essential for pharmaceutical R&D laboratories, analytical testing facilities, and manufacturers engaged in the development and quality control of related active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Reference Standard: Used as a certified reference material (CRM) for the identification, assay, and impurity profiling of related APIs in quality control laboratories.
• Metabolite Studies: Serves as a critical analytical standard for the identification and quantification of metabolites in pharmacokinetic and bioequivalence studies.
• Process Research & Development (R&D): Employed as a building block or intermediate in the synthetic pathway development for novel therapeutic compounds.
• Analytical Method Development: Utilized to develop and validate sensitive HPLC, LC-MS, or GC-MS methods for detection and quantification.
• Impurity Characterization: Acts as a known impurity standard to monitor and control the quality of bulk pharmaceutical products.
• Academic and Clinical Research: Supports fundamental research into the structure-activity relationships (SAR) and metabolic pathways of PDE5 inhibitors.

Basic Information

Item	Detail
Product Name	Desmethyl Fondenafil
CAS No.	147676-79-7
Molecular Formula	C22H30N6O4S
Molecular Weight	474.58 g/mol
Synonyms	N-Desmethyl Fondenafil; 5-[2-Ethoxy-5-[(4-methylpiperazin-1-yl)sulfonyl]phenyl]-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one; Fondenafil Desmethyl Impurity; Fondenafil N-Desmethyl; Fondenafil Metabolite; PDE5 Inhibitor Intermediate; 1-Methyl-3-propyl-5-[5-(4-methyl-1-piperazinylsulfonyl)-2-ethoxyphenyl]-1,6-dihydro-7H-pyrazolo[4,3-d]pyrimidin-7-one
EINECS	Contact for details

Quality Control

Our Desmethyl Fondenafil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by IR and NMR, purity determination by HPLC, and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with your research and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container sealed to protect the contents from moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.