Description

L-Prolinamide, (2R)-2-Butyl-n-Formyl-n-Hydroxy-β-Alanyl-n-(5-Fluoro-1-Oxido-2-Pyridinyl)- is a complex, non-natural amino acid derivative with a defined stereocenter, making it a valuable chiral building block for advanced organic synthesis. Its intricate structure, featuring a prolinamide core, a formyl-hydroxy alanyl chain, and a fluorinated pyridinyl N-oxide moiety, is engineered for high-value applications in pharmaceutical research and development. This compound is primarily targeted at medicinal chemists and process development scientists in the pharmaceutical and biotechnology industries seeking to develop novel therapeutic agents.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and synthesis of novel active pharmaceutical ingredients (APIs), particularly for complex small-molecule drugs.
• Peptidomimetic Research: Used in the design and construction of peptidomimetics and constrained peptides due to its proline-derived, conformationally restricted backbone.
• Medicinal Chemistry Library Building: Employed as a sophisticated scaffold for creating focused chemical libraries aimed at high-throughput screening for new drug candidates.
• Process Chemistry & Scale-Up: Acts as a key starting material or intermediate in the development and optimization of scalable synthetic routes for potential drug candidates.
• Bioconjugation & Probe Development: Its functional groups make it suitable for developing chemical probes, linkers, or tags for biochemical and biophysical studies.

Basic Information

Product Name	L-Prolinamide, (2R)-2-Butyl-n-Formyl-n-Hydroxy-β-Alanyl-n-(5-Fluoro-1-Oxido-2-Pyridinyl)-
CAS No.	478913-91-6
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2R)-2-Butyl-N-formyl-N-hydroxy-β-alanyl-N-(5-fluoro-1-oxido-2-pyridinyl)-L-prolinamide; (2R)-2-Butyl-N-formyl-N-hydroxy-β-alanyl-N-(5-fluoro-1-oxidopyridin-1-ium-2-yl)-L-prolinamide; 478913-91-6; L-Prolinamide derivative with 5-fluoro-2-pyridone N-oxide; Chiral Prolinamide Building Block
EINECS	Contact for details

Quality Control

Our high-purity L-Prolinamide derivative is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and NMR and MS for structural confirmation. We provide detailed Certificates of Analysis (COA) with every shipment, ensuring full traceability and compliance with the stringent requirements of research and pre-clinical development.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and handled under conditions that minimize exposure to ambient light and humidity to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Chiral Purity	≥ 98.0% ee
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.