Description

2-[1,2-13C2,15N]Acetamido-2-Deoxy-D-[Ul-13C6]Glucose is a highly specialized, multi-labeled stable isotope derivative of N-acetylglucosamine (GlcNAc). This compound is essential for advanced metabolic research, providing a powerful tracer for studying glycosylation pathways, carbohydrate metabolism, and cell wall biosynthesis with exceptional precision. It is primarily used by research scientists and pharmaceutical developers in metabolomics, glycobiology, and drug discovery programs requiring high-fidelity isotopic labeling.

Application

• Metabolic Flux Analysis (MFA): As a multi-isotope labeled precursor (13C, 15N) for tracing the incorporation of GlcNAc into glycoproteins, glycolipids, and peptidoglycans in bacterial and eukaryotic systems.
• Glycobiology Research: Investigating the biosynthesis and turnover of O-GlcNAcylated proteins, hyaluronic acid, and other glycosaminoglycans (GAGs) using mass spectrometry (MS) and nuclear magnetic resonance (NMR).
• Pharmaceutical Development: Serving as an internal standard for the quantitative bioanalysis of GlcNAc and related metabolites in pharmacokinetic and pharmacodynamic (PK/PD) studies.
• Microbial Physiology Studies: Probing bacterial cell wall synthesis and antibiotic mode of action, particularly relevant for pathogens where peptidoglycan is a key target.
• Stable Isotope Labeling by Amino acids in Cell culture (SILAC) Extensions: Enabling precise proteomic studies of glycosylation dynamics when combined with labeled amino acids.
• Diagnostic Assay Development: Used in the synthesis of labeled probes and standards for clinical diagnostics related to metabolic disorders.

Basic Information

Item	Detail
Product Name	2-[1,2-13C2,15N]Acetamido-2-Deoxy-D-[Ul-13C6]Glucose
CAS No.	478529-44-1
Molecular Formula	C813C6H1515NO6
Molecular Weight	~226.18 (for unlabeled C8H15NO6). Contact for exact labeled MW.
Synonyms	N-Acetyl-D-[Ul-13C6]glucosamine-1,2-13C2,15N; [1,2-13C2,15N; Ul-13C6]-N-Acetylglucosamine; Labeled GlcNAc; 2-Acetamido-2-deoxy-D-[Ul-13C6]glucose-1,2-13C2,15N; Stable Isotope N-Acetylglucosamine; 13C6,15N,13C2-GlcNAc; NAG-13C6,15N,13C2
EINECS	Contact for details

Quality Control

Every batch of our stable isotope-labeled compounds is produced and analyzed under strict quality protocols to ensure isotopic and chemical purity. Identity and purity are confirmed by advanced analytical techniques including NMR, HPLC, and Mass Spectrometry. Certificates of Analysis (COA) are provided with each shipment, detailing isotopic enrichment (Atom % 13C and 15N), chemical purity, and solvent content. Our quality system supports research requiring compliance with GMP/GLP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This material is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98% (chemical purity)
Isotopic Enrichment	≥ 99% Atom % 13C (UL-13C6) ≥ 99% Atom % 13C (1,2-13C2) ≥ 98% Atom % 15N
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.