Description

Tri-o-Acetyl-D-[1-13C]Glucal is a stable isotope-labeled derivative of glucal, specifically enriched with carbon-13 at the C-1 position and protected with acetyl groups. This compound is a critical intermediate for the synthesis of isotopically labeled carbohydrates, glycoconjugates, and nucleosides, enabling advanced metabolic and pharmacokinetic studies. It is primarily utilized by research institutions, pharmaceutical companies, and CROs specializing in tracer analysis, drug development, and mechanistic biochemical research.

Application

• Tracer Synthesis: A key precursor for the preparation of 13C-labeled sugars, glycolipids, and glycoproteins for use in metabolic flux analysis and NMR-based studies.
• Pharmaceutical Research: Used in the development and metabolic profiling of carbohydrate-based drugs, antivirals, and glycosidase inhibitors.
• Glycochemistry: Serves as a versatile building block in the stereoselective synthesis of complex oligosaccharides and glycomimetics.
• Nucleoside Analog Production: An intermediate in the synthesis of isotopically labeled nucleosides for antiviral and anticancer research.
• Biochemical Probes: Enables the creation of molecular probes for investigating glycosylation pathways and enzyme mechanisms.
• Stable Isotope Labeling: Essential for Mass Spectrometry (MS) and Nuclear Magnetic Resonance (NMR) spectroscopy applications requiring internal standards or tracers.

Basic Information

Product Name	Tri-o-Acetyl-D-[1-13C]Glucal
CAS No.	478529-35-0
Molecular Formula	C12H1613CO8
Molecular Weight	289.25 g/mol (for 13C1 isotopologue)
Synonyms	1,5-Anhydro-2-deoxy-1-(13C)arabino-hex-1-enitol Triacetate; D-[1-13C]Glucal Triacetate; (3aR,5R,6S,6aR)-5-(Acetyloxy)-6-((acetyloxy)methyl)-2-methyl-3a,5,6,6a-tetrahydrofuro[2,3-d][1,3]dioxol-4-yl acetate-1-13C; Tri-O-acetyl-1,5-anhydro-2-deoxy-D-arabino-hex-1-enitol-1-13C; 13C1-Labeled Tri-O-acetyl-D-glucal
EINECS	Contact for details

Quality Control

Every batch of Tri-o-Acetyl-D-[1-13C]Glucal is manufactured and analyzed under strict quality protocols to ensure isotopic and chemical purity for sensitive research applications. Our quality assurance includes comprehensive testing for isotopic enrichment, chemical purity, and identity. Certificates of Analysis (COA) are provided with each shipment, detailing batch-specific results from NMR, HPLC, and MS analysis.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and light-sensitive; containers must be kept sealed under an inert atmosphere (e.g., argon or nitrogen) when not in use to maintain stability and prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (NMR)	Conforms to structure
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Chemical Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.