Description

D-[1,3-13C2]Glucose is a stable isotope-labeled analog of D-glucose, specifically enriched with carbon-13 at the 1 and 3 positions. This precise labeling is critical for advanced metabolic research, enabling the accurate tracing of glucose utilization and carbon flux in complex biochemical pathways. It is an essential tool for researchers and scientists in pharmaceutical development, clinical diagnostics, metabolic flux analysis (MFA), and nutritional studies who require high-purity, isotopically defined substrates.

Application

• Metabolic Flux Analysis (MFA): Used as a tracer to quantify intracellular metabolic pathway activities in cell cultures, tissues, and whole organisms.
• Pharmaceutical R&D: Employed in drug metabolism and pharmacokinetics (DMPK) studies to investigate the metabolic fate of new chemical entities.
• Clinical Research: Serves as a diagnostic probe in stable isotope breath tests (e.g., for assessing liver function or bacterial overgrowth).
• Nutritional Science: Applied in studies of carbohydrate metabolism, insulin resistance, and energy homeostasis.
• Biotechnology: Utilized in the development and optimization of microbial fermentation processes for bio-production.
• NMR Spectroscopy: Acts as a standard or tracer in nuclear magnetic resonance studies due to its distinct 13C signature.

Basic Information

Product Name	D-[1,3-13C2]Glucose
CAS No.	478529-30-5
Molecular Formula	C6H12O6 (13C labeled at positions 1 & 3)
Molecular Weight	182.15 g/mol (approx., based on isotopic enrichment)
Synonyms	1,3-13C2-Glucose; D-Glucose-1,3-13C2; [1,3-13C2]-D-Glucopyranose; (2R,3S,4R,5R)-2,3,4,5,6-Pentahydroxyhexanal-1,3-13C2; Isotopically Labeled Glucose; 13C2-Glucose; Stable Isotope-Labeled Glucose; Glucose Tracer
EINECS	Contact for details

Quality Control

Every batch of D-[1,3-13C2]Glucose is manufactured and analyzed under strict quality protocols to ensure exceptional isotopic and chemical purity, which is paramount for sensitive tracer studies. Our products undergo rigorous quality testing, including NMR and LC-MS analysis, to ensure compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing isotopic enrichment (atom % 13C), chemical purity, and specific analytical data is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Complies
Isotopic Enrichment (Atom % 13C)	≥ 99% at each labeled position
Chemical Purity (HPLC)	≥ 98.0%
Specific Optical Rotation	+52.5° to +53.0° (c=10, H2O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.