Description

[1'-13C]Guanosine Monohydrate CAS NO 478511-32-9 is a stable isotope-labeled nucleoside, specifically guanosine monohydrate with a carbon-13 label at the 1' position of the ribose sugar. This precise labeling is critical for advanced research requiring high-fidelity metabolic and pharmacokinetic tracing. It is an essential biochemical tool for scientists in pharmaceutical development, metabolic research, and analytical chemistry who require uncompromised isotopic purity and structural integrity for their studies.

Application

• Isotope Tracer Studies: Used as a metabolic tracer in NMR spectroscopy and mass spectrometry to investigate nucleotide and nucleic acid biosynthesis pathways.
• Drug Metabolism and Pharmacokinetics (DMPK): Serves as an internal standard for the quantitative analysis of guanosine and its metabolites in biological matrices via LC-MS/MS.
• Biochemical Research: Employed in enzymatic studies to elucidate reaction mechanisms and kinetics involving guanylate metabolism.
• Pharmaceutical Development: Integral for labeling candidate drug molecules to study their absorption, distribution, metabolism, and excretion (ADME) profiles.
• Diagnostic Agent Development: Potential use in the synthesis of labeled probes for molecular imaging and diagnostic applications.

Basic Information

Product Name	[1'-13C]Guanosine Monohydrate
CAS No.	478511-32-9
Molecular Formula	C1013CH14N5O6 • H2O
Molecular Weight	302.24 g/mol (for 13C1 labeled form)
Synonyms	1'-Carbon-13 Guanosine Monohydrate; [1'-13C]Guanosine Hydrate; 9-β-D-Ribofuranosyl[1'-13C]guanine Monohydrate; Guanosine-1'-13C Monohydrate; Labeled Guanosine; 13C1-Guanosine Monohydrate; Isotopic Guanosine; Stable Isotope-Labeled Nucleoside
EINECS	Contact for details

Quality Control

Our [1'-13C]Guanosine Monohydrate is manufactured under strict quality systems to ensure exceptional isotopic and chemical purity for research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (Atom % 13C), chemical purity by HPLC, and identity confirmation. We ensure compliance with relevant standards for research-grade biochemicals.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccation. Keep container tightly sealed when not in use to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Isotopic Enrichment (Atom % 13C)	≥ 99%
Chemical Purity (HPLC)	≥ 98.0%
Water Content (KF)	5.0 - 7.5% (Theoretical for monohydrate: ~5.96%)
Specific Rotation	Contact for details
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.