Description

[2'-13C]2'-Deoxycytidine Monohydrate CAS NO 478511-23-8 is a stable isotope-labeled nucleoside derivative, specifically deuterated at the 2' position of the deoxyribose sugar. This compound is essential for advanced research requiring precise metabolic and pharmacokinetic tracing in nucleic acid synthesis and related pathways. It is a critical reagent for scientists and manufacturers in pharmaceutical development, metabolic research, and diagnostic assay production, where isotopic labeling is necessary for mass spectrometry (MS) and nuclear magnetic resonance (NMR) studies.

Application

• Isotopic Tracer in Metabolic Studies: Used to investigate the synthesis, turnover, and catabolism of DNA and related nucleotides in cell culture and in vivo models.
• Internal Standard for Mass Spectrometry: Serves as a critical quantitative internal standard in LC-MS/MS and GC-MS assays for accurate measurement of deoxycytidine and its metabolites in biological matrices.
• NMR Spectroscopy Research: Enables detailed structural and dynamic studies of nucleic acids and enzymatic mechanisms due to the 13C label.
• Pharmaceutical R&D for Antiviral/Cancer Drugs: Employed in the development and metabolic pathway analysis of nucleoside analog therapeutics.
• Diagnostic Kit Manufacturing: Integrated into high-precision clinical diagnostic kits for quantifying genetic material or specific metabolic disorders.
• Biochemical Pathway Elucidation: Aids in mapping anabolic and catabolic pathways involving pyrimidine metabolism.

Basic Information

Product Name	[2'-13C]2'-Deoxycytidine Monohydrate
CAS No.	478511-23-8
Molecular Formula	C9¹³CH15N3O5 • H2O
Molecular Weight	263.23 g/mol (approx.)
Synonyms	2'-Deoxycytidine-2'-13C monohydrate; 1-(2-Deoxy-2-13C-β-D-ribofuranosyl)cytosine monohydrate; Cytosine deoxyribonucleoside-2'-13C monohydrate; 2'-13C-dCyd; 2'-13C-Labeled 2'-Deoxycytidine; 2'-13C-2'-Deoxycytidine hydrate; dC-2'-13C
EINECS	Contact for details

Quality Control

Every batch of [2'-13C]2'-Deoxycytidine Monohydrate is manufactured and analyzed under strict quality systems. We guarantee high chemical and isotopic purity, with comprehensive testing including HPLC for chemical purity, NMR and MS for isotopic enrichment verification, and stringent controls for moisture content and residual solvents. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant use. Keep container sealed when not in use to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Enrichment (13C)	≥ 99 atom % 13C
Water Content (KF)	5.0% - 8.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.