Description

5-Methyl-[5'-13C]Uridine is a stable isotope-labeled nucleoside analog, specifically labeled with carbon-13 at the 5' position of the ribose sugar. This precise labeling is critical for advanced research applications requiring high sensitivity and specificity in metabolic and pharmacokinetic studies. It is an essential tool for scientists in pharmaceutical R&D, academic research, and diagnostic development, particularly for use as an internal standard in mass spectrometry (LC-MS/MS) to ensure accurate quantification.

Application

• Mass Spectrometry Internal Standard: Primary use as a quantitative reference standard in LC-MS/MS for the analysis of nucleoside metabolism and related drug compounds.
• Metabolic Pathway Tracing: Employed in isotope tracing studies to investigate the biosynthesis, turnover, and catabolism of RNA and related metabolites.
• Pharmaceutical R&D: Used in the development and validation of bioanalytical methods for novel antiviral or anticancer nucleoside analogs.
• Clinical Research: Facilitates accurate measurement of modified nucleosides that may serve as potential biomarkers in physiological or disease states.
• Stable Isotope Labeling: Serves as a building block for the synthesis of more complex isotopically labeled compounds for research.

Basic Information

Product Name	5-Methyl-[5'-13C]Uridine
CAS No.	478511-02-3
Molecular Formula	C10H1413CN2O6
Molecular Weight	Contact for details
Synonyms	5-Methyluridine-5'-13C; [5'-13C]-5-Methyluridine; 5-Methyl-2'-deoxyuridine-5'-13C (common misnomer); 1-((2R,3R,4S,5R)-3,4-Dihydroxy-5-((hydroxymethyl-13C)methyl)tetrahydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione; m5U-5'-13C; Isotopically Labeled Uridine Derivative
EINECS	Contact for details

Quality Control

Our 5-Methyl-[5'-13C]Uridine is manufactured under strict quality control protocols to ensure the highest isotopic and chemical purity for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing results for isotopic enrichment (by NMR or MS), chemical purity (by HPLC), and identity confirmation. We support compliance with relevant research and development standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This compound is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/MS)	Conforms
Isotopic Enrichment	≥ 99 atom % 13C
Purity (HPLC)	≥ 98%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.