Description

(S)-Bel CAS NO 478288-94-7 is a high-purity chiral intermediate of significant importance in modern pharmaceutical synthesis. Its primary value lies in its role as a key building block for the development of enantiomerically pure active pharmaceutical ingredients (APIs), where stereochemical control is critical for efficacy and safety. This compound is essential for research and production teams in the pharmaceutical and fine chemical industries focused on creating novel therapeutics, particularly in areas requiring specific stereochemistry.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of enantiomerically pure Active Pharmaceutical Ingredients (APIs).
• Asymmetric Synthesis: Used as a starting material or reagent in catalytic asymmetric reactions to introduce stereogenic centers.
• Medicinal Chemistry Research: Employed in drug discovery programs for the design and optimization of novel therapeutic candidates with specific stereochemistry.
• Process Chemistry Development: Serves as a key intermediate in scaling up synthetic routes from laboratory to pilot plant and commercial manufacturing.
• Reference Standard: Utilized as a high-purity standard for analytical method development, validation, and quality control in pharmaceutical analysis.
• Fine Chemical Synthesis: Applied in the production of other complex, high-value chiral molecules for various advanced applications.

Basic Information

Product Name	(S)-Bel
CAS No.	478288-94-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(S)-Bel; (S)-Belnifos; (S)-Belnifosbuvir intermediate; Belnifosbuvir (S)-isomer intermediate; (S)-Isomer of 478288-90-3; GS-9669 (S)-enantiomer intermediate; Antiviral nucleotide analog intermediate (S)-form; (S)-configuration phosphoramidate prodrug intermediate
EINECS	Contact for details

Quality Control

Our (S)-Bel is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Quality is verified through comprehensive analytical testing, including chiral purity assays. A Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment, supporting compliance with cGMP and ICH guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area. For long-term storage, consider conditions of 2-8°C. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% ee
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.