Description

6-(tert-Butyl)-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is a specialized pyridine derivative that serves as a high-value synthetic intermediate in advanced organic chemistry. Its molecular structure, featuring a trifluoromethyl group and a nitrile functionality, makes it a critical building block for constructing complex molecules with tailored properties. This compound is primarily utilized by research and development teams in the pharmaceutical and agrochemical sectors for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Research: Used in the development of new-generation herbicides and fungicides, where the trifluoromethyl group enhances biological activity and environmental stability.
• Material Science: Building block for creating functionalized ligands and organic frameworks used in catalysis and advanced materials.
• Chemical Synthesis: Versatile intermediate for introducing the 2-hydroxy-4-(trifluoromethyl)nicotinonitrile scaffold into more complex heterocyclic systems.
• Academic & Contract Research: Employed in university and CRO laboratories for methodological studies and the discovery of new chemical entities.

Basic Information

Product Name	6-(tert-Butyl)-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile
CAS No.	478049-68-2
Molecular Formula	C11H11F3N2O
Molecular Weight	244.22 g/mol
Synonyms	2-Hydroxy-6-(tert-butyl)-4-(trifluoromethyl)nicotinonitrile; 6-tert-Butyl-2-hydroxy-4-(trifluoromethyl)pyridine-3-carbonitrile; 4-(Trifluoromethyl)-6-(tert-butyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile; 2-Oxo-6-tert-butyl-4-trifluoromethyl-1,2-dihydropyridine-3-carbonitrile; 6-(1,1-Dimethylethyl)-2-hydroxy-4-(trifluoromethyl)-3-pyridinecarbonitrile
EINECS	Contact for details

Quality Control

Every batch of 6-(tert-Butyl)-2-Hydroxy-4-(Trifluoromethyl)Nicotinonitrile is manufactured under a strict quality management system and undergoes comprehensive analytical testing. We ensure compliance with the stringent requirements of our global pharmaceutical and agrochemical partners. A detailed Certificate of Analysis (COA), including purity by HPLC, identity confirmation (IR, NMR), and impurity profile, is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Related Substances (HPLC)	Individual impurity ≤ 0.5%; Total impurities ≤ 1.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.