Description

3-tert-Butoxycarbonylamino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is a high-value, protected amino acid derivative featuring a trifluoromethylphenyl side chain, making it a critical building block in advanced organic synthesis. Its primary value lies in its role as a key chiral intermediate for constructing complex molecules, particularly in pharmaceutical research and development. This compound is essential for medicinal chemists and process development scientists working on novel active pharmaceutical ingredients (APIs), especially in therapeutic areas like oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of peptide mimetics and small molecule drug candidates targeting various diseases.
• Protease Inhibitor Development: Used in the research and production of inhibitors for enzymes like proteases, where the trifluoromethyl group enhances binding affinity and metabolic stability.
• Peptidomimetic Chemistry: Serves as a backbone component for creating non-peptide compounds that mimic the structure and function of natural peptides.
• Chemical Biology Probes: Employed in the design and synthesis of labeled compounds and probes for studying biological pathways and target engagement.
• Agrochemical Research: Acts as an intermediate in the development of advanced agrochemicals with improved activity and environmental profiles.
• Material Science: Potential use as a monomer or precursor for specialized polymers and advanced materials with unique properties.

Basic Information

Product Name	3-tert-Butoxycarbonylamino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid
CAS No.	477849-00-6
Molecular Formula	C15H18F3NO4
Molecular Weight	333.31 g/mol
Synonyms	Boc-3-amino-3-(4-(trifluoromethyl)phenyl)propanoic acid; N-Boc-3-amino-3-(4-trifluoromethylphenyl)propionic acid; 3-[(tert-Butoxycarbonyl)amino]-3-[4-(trifluoromethyl)phenyl]propanoic acid; (R/S)-3-(Boc-amino)-3-(4-trifluoromethylphenyl)propionic acid; 3-(N-Boc-amino)-3-(4-trifluoromethylphenyl)propanoic acid; Boc-β-(4-Trifluoromethylphenyl)-β-alanine; N-Boc-β-(4-Trifluoromethylphenyl)-β-alanine
EINECS	Contact for details

Quality Control

Our 3-tert-Butoxycarbonylamino-3-(4-Trifluoromethyl-Phenyl)-Propionic Acid is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets the high standards required for research and development applications. Certificates of Analysis (COA) with detailed chromatographic data are provided for every shipment, ensuring full traceability and compliance with your internal quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere such as nitrogen or argon.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee (for enantiopure grade)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.