Description

2-Acetamido-5-Fluoro-4-Picoline is a specialized heterocyclic building block featuring a picoline core substituted with fluorine and an acetamido group. This compound matters as a high-value intermediate in modern synthetic chemistry, enabling the construction of complex molecules with precise functionality. It is primarily needed by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and oncology.
• Agrochemical Research: Used in the development of new herbicides, fungicides, and insecticides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Material Science: Serves as a precursor for creating advanced organic ligands and functionalized polymers with specific electronic or photophysical properties.
• Chemical Synthesis: Employed in academic and industrial R&D for constructing complex heterocyclic frameworks and fluorinated compounds.
• Ligand & Catalyst Development: Useful for synthesizing novel chelating agents and organocatalysts used in asymmetric synthesis and metal-catalyzed reactions.

Basic Information

Product Name	2-Acetamido-5-Fluoro-4-Picoline
CAS No.	475060-21-0
Molecular Formula	C8H9FN2O
Molecular Weight	168.17 g/mol
Synonyms	N-(5-Fluoro-4-methylpyridin-2-yl)acetamide; 2-Acetylamino-5-fluoro-4-methylpyridine; 5-Fluoro-2-acetamido-4-picoline; 2-Acetamido-5-fluoro-4-methylpyridine; Acetamide, N-(5-fluoro-4-methyl-2-pyridinyl)-; 5-Fluoro-4-methyl-2-pyridinamine, N-acetyl-
EINECS	Contact for details

Quality Control

Our 2-Acetamido-5-Fluoro-4-Picoline is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process development. Certificates of Analysis (COA) documenting all critical quality attributes are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.