Description

8-Isoprostaglandin A2 CAS NO 474391-66-7 is a specialized isoprostane compound, a class of prostaglandin-like molecules formed non-enzymatically from the free radical-catalyzed peroxidation of arachidonic acid. This compound is of significant value as a biomarker for oxidative stress and as a reference standard in analytical and biochemical research. It is primarily required by researchers and quality control laboratories in the pharmaceutical, biotechnology, and life sciences sectors for advanced studies in lipid peroxidation, inflammation, and related disease mechanisms.

Application

• Biomarker Standard for Oxidative Stress: Used as a high-purity reference material in LC-MS/MS and GC-MS methods to quantify oxidative damage in biological samples.
• Pharmaceutical Research & Development: Serves as a critical analytical standard in drug discovery programs targeting inflammation, cardiovascular diseases, and neurodegenerative disorders.
• Clinical Diagnostics Development: Employed in the development and validation of diagnostic assays to measure isoprostane levels as indicators of disease states.
• Biochemical Research: Utilized in vitro and in vivo studies to investigate the biological activity and signaling pathways of isoprostanes.
• Quality Control & Method Validation: Essential for calibrating equipment and validating analytical methods in contract research organizations (CROs) and testing laboratories.
• Academic Research: A key reagent for universities and research institutes studying free radical biology, lipid metabolism, and aging.

Basic Information

Item	Details
Product Name	8-Isoprostaglandin A2
CAS No.	474391-66-7
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	8-iso-PGA2; 8-iso-Prostaglandin A2; 15-F2t-IsoP A2; 8-Epi-prostaglandin A2; IsoPGA2; (5Z)-7-{(1R,2R,3R,5S)-5-[(1E,3S)-3-Hydroxyoct-1-en-1-yl]-2-[(1E,3S)-3-hydroxyoct-1-en-1-yl]cyclopent-3-en-1-yl}hept-5-enoic acid
EINECS	Contact for details

Quality Control

Our 8-Isoprostaglandin A2 is produced and handled under strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive research applications. Each lot undergoes comprehensive analytical characterization, including purity assessment by HPLC. A Certificate of Analysis (COA) detailing identity, purity, and analytical data is provided with every shipment to support your regulatory and quality documentation needs.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Allow the sealed vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Solubility	Soluble in ethanol, DMSO; slightly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.