Description

Insulin-Like Growth Factor-1 Receptor Inhibitor CAS NO 468740-43-4 is a potent and selective small molecule inhibitor targeting the IGF-1R tyrosine kinase, a key receptor implicated in cellular growth, proliferation, and survival signaling pathways. This compound is crucial for research and development in oncology and metabolic disorders, where dysregulated IGF-1R signaling is a therapeutic target. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies engaged in drug discovery and preclinical studies.

Application

• Oncology Research: Used as a critical tool compound to study the role of IGF-1R signaling in tumor cell proliferation, metastasis, and resistance to chemotherapy.
• Drug Discovery & Development: Serves as a reference standard and a lead compound in the development of novel anti-cancer therapeutics targeting receptor tyrosine kinases.
• Biochemical Assays: Employed in high-throughput screening (HTS) and in vitro kinase inhibition assays to evaluate potency and selectivity profiles.
• Mechanistic Studies: Facilitates the investigation of downstream signaling pathways, including PI3K/AKT and MAPK/ERK, in various cell lines and disease models.
• Preclinical In Vivo Studies: Utilized in animal models to assess the efficacy, pharmacokinetics, and pharmacodynamics of IGF-1R inhibition.
• Metabolic Disorder Research: Applied in studies exploring the connection between IGF-1R signaling, insulin resistance, and related metabolic syndromes.

Basic Information

Product Name	Insulin-Like Growth Factor-1 Receptor Inhibitor
CAS No.	468740-43-4
Molecular Formula	C₂₃H₂₁ClFN₅O₃
Molecular Weight	469.90 g/mol
Synonyms	NVP-AEW541; AEW541; IGF-1R Inhibitor VIII; 1H-Pyrrolo[2,3-b]pyridine derivative AEW541; (3Z)-5-Chloro-3-[(3,5-dimethyl-4-[(4-methylpiperazin-1-yl)carbonyl]-1H-pyrrol-2-yl)methylidene]-1,3-dihydro-2H-indol-2-one; IGF1R Inhibitor
EINECS	Contact for details

Quality Control

Our Insulin-Like Growth Factor-1 Receptor Inhibitor is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade standards. Specifications are designed to meet the rigorous demands of pharmaceutical R&D.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This compound is hygroscopic (moisture-sensitive); ensure containers are sealed tightly after each use to minimize exposure to atmospheric moisture. For long-term storage, keep desiccated.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines
Assay	95.0% - 105.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.