Description

Alvespimycin is a potent and selective inhibitor of the Hsp90 molecular chaperone, a key target in oncology research. This compound is critical for studying protein folding, client protein degradation, and the cellular stress response in various disease models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in cancer therapeutics development and molecular biology.

Application

• Oncology Research: Used as a research tool to investigate Hsp90 inhibition as a mechanism for inducing apoptosis in cancer cell lines.
• Preclinical Drug Development: Serves as a reference compound or lead molecule in the discovery and optimization of novel Hsp90-targeted therapies.
• Molecular Biology Studies: Employed to study the role of Hsp90 in protein homeostasis, signal transduction pathways, and cellular response to stress.
• Biochemical Assays: Used in high-throughput screening (HTS) and in vitro assays to evaluate Hsp90 inhibitor potency and selectivity.
• Combination Therapy Research: Investigated for potential synergistic effects when used alongside other chemotherapeutic agents or targeted therapies.

Basic Information

Product Name	Alvespimycin
CAS No.	467214-20-6
Molecular Formula	C₃₁H₄₃N₃O₈
Molecular Weight	585.69 g/mol
Synonyms	17-DMAG; 17-Dimethylaminoethylamino-17-demethoxygeldanamycin; Alvespimycin hydrochloride; KOS-1022; BMS 826476; NSC 707545; 17-(2-Dimethylaminoethyl)amino-17-demethoxygeldanamycin
EINECS	Contact for details

Quality Control

Our Alvespimycin is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation (NMR, MS), to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting purity, potency, and full analytical data.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere. This product is hygroscopic (moisture-sensitive) and easily oxidized; allow the vial to equilibrate to room temperature in a desiccator before opening to minimize exposure to moisture and air.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, Methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.