Description

o-Desmethyl Galanthamine B-D-Glucuronide is a key metabolite and reference standard of galantamine, a cholinesterase inhibitor used in the treatment of cognitive disorders. This high-purity compound is essential for pharmaceutical research and development, particularly in the study of drug metabolism, pharmacokinetics, and bioanalytical method validation. It is primarily utilized by research institutions, pharmaceutical companies, and contract research organizations (CROs) involved in neuroscience and analytical chemistry.

Application

• Pharmacokinetic and Metabolism Studies: Used as a critical reference standard to quantify and characterize the glucuronidated metabolite of galantamine in biological matrices.
• Bioanalytical Method Development: Serves as a primary standard for calibrating HPLC, LC-MS, and LC-MS/MS systems in method validation for clinical and preclinical trials.
• DMPK (Drug Metabolism and Pharmacokinetics) Research: Enables detailed investigation of the metabolic pathways and clearance mechanisms of galantamine.
• Impurity Profiling and Characterization: Acts as a known impurity or degradation product standard for the quality control of galantamine active pharmaceutical ingredients (APIs).
• Regulatory Compliance and Documentation: Supports regulatory filings (e.g., for FDA, EMA) by providing authenticated material for study data packages.

Basic Information

Product Name	o-Desmethyl Galanthamine B-D-Glucuronide
CAS No.	464189-54-6
Molecular Formula	C23H29NO9
Molecular Weight	463.48 g/mol
Synonyms	O-Desmethyl Galantamine B-D-Glucuronide; N-Desmethyl Galantamine Glucuronide; Galantamine Metabolite Glucuronide; 4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-ol, 9-Glucuronide; (4aS,6R,8aS)-4a,5,9,10,11,12-Hexahydro-3-methoxy-11-methyl-6H-benzofuro[3a,3,2-ef][2]benzazepin-6-yl β-D-Glucopyranosiduronic Acid
EINECS	Contact for details

Quality Control

Our o-Desmethyl Galanthamine B-D-Glucuronide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for reference materials. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤5.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.