Description

Ko 143 CAS NO 461054-93-3 is a potent and selective small molecule inhibitor primarily used in biochemical and pharmacological research. This compound is valued for its high specificity in targeting key cellular pathways, making it an essential tool for mechanistic studies and drug discovery. It is primarily utilized by researchers and development teams in the pharmaceutical, biotechnology, and academic sectors for investigating cancer biology, signal transduction, and other critical disease mechanisms.

Application

• Biochemical Research: Used as a selective inhibitor in enzymatic assays and pathway analysis to study specific protein functions.
• Cancer Research: Investigated for its role in modulating cellular proliferation and apoptosis in various cancer cell lines.
• Signal Transduction Studies: Employed to dissect and validate key signaling pathways involved in cell growth and differentiation.
• Drug Discovery & Development: Serves as a reference compound or a lead molecule in high-throughput screening and preclinical studies.
• Academic Research: Utilized in university and institutional labs for fundamental research in molecular and cellular biology.
• Pharmaceutical R&D: Applied in target validation and the development of novel therapeutic agents.

Basic Information

Product Name	Ko 143
CAS No.	461054-93-3
Molecular Formula	C₂₆H₂₇F₃N₄O₃
Molecular Weight	500.51 g/mol
Synonyms	Ko-143; Ko143; (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester; Elacridar analog; Fumitremorgin C analog; BCRP inhibitor; ABCG2 inhibitor
EINECS	Contact for details

Quality Control

Our Ko 143 is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity verification and NMR/LC-MS for structural confirmation, to ensure it meets the high standards required for research applications. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability, consistency, and reliability for your critical work.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.