Description

4-Imidazolidinemethanesulfonyl Chloride, 4-Methyl-2,5-Dioxo-, (4R)- is a high-purity, chiral building block of significant interest in advanced organic synthesis. Its value lies in its role as a key intermediate for constructing complex molecules with defined stereochemistry, which is critical for developing active pharmaceutical ingredients (APIs). This compound is essential for research and production chemists in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for drug discovery and process development.

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates, particularly in the development of protease inhibitors and other biologically active molecules.
• Agrochemical Research: Used in the creation of advanced, stereospecific pesticides and herbicides where the specific (4R) configuration can influence biological activity.
• Peptidomimetic Chemistry: Serves as a constrained scaffold for designing peptide analogs and mimetics in medicinal chemistry programs.
• Chemical Biology Probes: Employed in the synthesis of specialized probes and labeled compounds for studying enzyme mechanisms and biological pathways.
• Asymmetric Synthesis: Acts as a starting material or intermediate in catalytic asymmetric reactions to introduce chiral centers into target molecules.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific advanced intermediates.

Basic Information

Product Name	4-Imidazolidinemethanesulfonyl Chloride, 4-Methyl-2,5-Dioxo-, (4R)-
CAS No.	459818-51-0
Molecular Formula	C5H7ClN2O4S
Molecular Weight	226.64 g/mol
Synonyms	(4R)-4-Methyl-2,5-dioxoimidazolidine-1-sulfonyl chloride; (R)-4-Methyl-2,5-dioxoimidazolidine-1-sulfonyl chloride; 1-Imidazolidinesulfonyl chloride, 4-methyl-2,5-dioxo-, (4R)-; (4R)-4-Methyl-2,5-dioxo-1-imidazolidinesulfonyl chloride; (R)-N-Sulfonylchloride of 4-methylhydantoin; Chiral hydantoin sulfonyl chloride; (R)-4-Methylhydantoin-1-sulfonyl chloride
EINECS	Contact for details

Quality Control

Our 4-Imidazolidinemethanesulfonyl Chloride, 4-Methyl-2,5-Dioxo-, (4R)- is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, suitable for demanding synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, chiral purity (enantiomeric excess), and impurity profiles. We adhere to cGMP (current Good Manufacturing Practice) guidelines where applicable, ensuring traceability and reliability for our global pharmaceutical and research clients.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be handled under anhydrous conditions to prevent decomposition. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.