Description

3-Fluoropyridine-4-Boronic Acid is a high-value, multi-functional organoboron building block essential for modern synthetic chemistry. Its core value lies in enabling efficient carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and agrochemical R&D. This compound is critically needed by researchers and process chemists in the pharmaceutical, agrochemical, and material science industries for constructing complex fluorinated heterocyclic scaffolds.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing novel active pharmaceutical ingredients (APIs), especially those containing fluoropyridine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where the fluoropyridine structure imparts specific biological activity.
• Material Science Research: Serves as a precursor for creating functionalized polymers, liquid crystals, and organic electronic materials through cross-coupling methodologies.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for imaging and diagnostic applications.
• Catalyst Ligand Synthesis: Useful for constructing sophisticated ligand systems for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A critical starting material for custom synthesis houses serving the life sciences sector.

Basic Information

Product Name	3-Fluoropyridine-4-Boronic Acid
CAS No.	458532-97-3
Molecular Formula	C5H5BFNO2
Molecular Weight	140.91 g/mol
Synonyms	(3-Fluoropyridin-4-yl)boronic Acid; 3-Fluoro-4-pyridineboronic Acid; 4-Borono-3-fluoropyridine; 3-Fluoro-4-pyridinylboronic Acid; 3-Fluoropyridine-4-boronic Acid Pinacol Ester (common derivative); 3-Fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Fluoro-4-pyridylboronic Acid
EINECS	Contact for details

Quality Control

Our 3-Fluoropyridine-4-Boronic Acid is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for moisture content, to ensure it meets the exacting standards required for sensitive coupling reactions. A detailed Certificate of Analysis (COA) is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C for long-term stability. This compound is easily oxidized and light-sensitive. Allow the sealed container to reach room temperature before opening to minimize moisture ingress.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF Titration)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.