Description

Jak Inhibitor I is a potent and selective small molecule inhibitor of the Janus kinase (JAK) family of enzymes, a key target in cellular signaling pathways. This compound is a critical research tool for investigating the role of JAK-STAT signaling in immunology, oncology, and inflammatory diseases. It is essential for pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on developing novel therapeutics for autoimmune disorders and hematological cancers.

Application

• Biomedical Research: Used as a selective biochemical tool to inhibit JAK kinases in cell-based assays and in vitro studies to elucidate signaling mechanisms.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in high-throughput screening and structure-activity relationship (SAR) studies for novel JAK inhibitors.
• Immunology Studies: Applied in research models to study cytokine signaling, T-cell activation, and the pathophysiology of autoimmune conditions like rheumatoid arthritis and psoriasis.
• Oncology Research: Utilized to investigate the role of JAK-STAT pathways in hematologic malignancies, including myeloproliferative neoplasms and leukemia.
• Signal Transduction Analysis: A key reagent for dissecting the JAK-STAT pathway's involvement in cellular proliferation, apoptosis, and immune response.
• Preclinical Studies: Employed in animal models to validate JAK as a therapeutic target and assess the efficacy of intervention strategies.

Basic Information

Product Name	Jak Inhibitor I
CAS No.	457081-03-7
Molecular Formula	C₂₃H₂₂N₈O
Molecular Weight	426.47 g/mol
Synonyms	1,2,3,4,5,6-Hexahydro-8,10-dimethoxy-2-methyl-11-(2-methylpropyl)-2,6-methano-6H-pyrazino[1,2-a][1,4]benzodiazepin-5-one; Pyrazolo[1,5-a]pyrimidine-3-carboxamide, 6-(Cyclopropylamino)-N-(2,4-difluorophenyl)-; JAK Inhibitor I; JAK Inhibitor; Janus Kinase Inhibitor I; CAS 457081-03-7
EINECS	Contact for details

Quality Control

Our Jak Inhibitor I is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity verification and NMR for structural confirmation, to ensure high batch-to-batch consistency and compliance with research-grade standards. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and potency. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.