Description

Benzenesulfonyl Fluoride, 5-Bromo-2-Methoxy- is a specialized organosulfur compound featuring a sulfonyl fluoride functional group, a key reactive handle in modern synthetic chemistry. This high-purity intermediate is critical for researchers and manufacturers requiring precise, reliable building blocks for complex molecule assembly. It is primarily utilized in pharmaceutical research, agrochemical development, and advanced materials science for applications such as covalent inhibitor synthesis and chemical probe development.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting enzymes via covalent inhibition.
• Chemical Biology Probe Development: Used to create activity-based probes (ABPs) for profiling enzyme families like serine hydrolases and proteases in complex biological systems.
• Agrochemical Synthesis: Serves as a precursor in the development of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Sulfonyl Fluoride Chemistry: Enables SuFEx (Sulfur(VI) Fluoride Exchange) click chemistry reactions for polymer science and bioconjugation.
• Material Science Research: Employed in the creation of functionalized surfaces, novel polymers, and advanced organic frameworks.
• Cross-Coupling Reactions: The bromo substituent makes it a suitable substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create diverse chemical libraries.

Basic Information

Product Name	Benzenesulfonyl Fluoride, 5-Bromo-2-Methoxy-
CAS No.	457051-09-1
Molecular Formula	C7H6BrFO3S
Molecular Weight	269.09 g/mol
Synonyms	5-Bromo-2-methoxybenzenesulfonyl fluoride; 2-Methoxy-5-bromobenzenesulfonyl fluoride; 1-Bromo-4-methoxy-2-sulfonylfluoridebenzene; 5-Bromo-2-methoxybenzene-1-sulfonyl fluoride; 2-Methoxy-5-bromophenylsulfonyl fluoride; 5-Bromo-o-anisolesulfonyl fluoride; (5-Bromo-2-methoxyphenyl)sulfonyl fluoride
EINECS	Contact for details

Quality Control

Our Benzenesulfonyl Fluoride, 5-Bromo-2-Methoxy- is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under inert atmosphere or in a desiccator to prevent decomposition. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥97.0%
Purity (GC)	≥96.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.