Description

2-Pyridinecarboxylic Acid, 4-(Trifluoromethyl)-, Methyl Ester is a high-value trifluoromethylated pyridine derivative, serving as a critical building block in advanced organic synthesis. Its core value lies in the unique combination of the pyridine scaffold and the electron-withdrawing trifluoromethyl group, which is essential for modulating the physicochemical properties of target molecules. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: Key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitor and central nervous system (CNS) drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the trifluoromethyl group improves lipophilicity and biological activity.
• Ligand and Catalyst Precursor: Serves as a starting material for synthesizing specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, such as electron-transport layers or components for OLEDs, due to its electron-deficient aromatic system.
• Custom Synthesis and Contract Manufacturing: A vital reagent for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	2-Pyridinecarboxylic Acid, 4-(Trifluoromethyl)-, Methyl Ester
CAS No.	455941-78-3
Molecular Formula	C8H6F3NO2
Molecular Weight	205.14 g/mol
Synonyms	Methyl 4-(trifluoromethyl)picolinate; 4-(Trifluoromethyl)picolinic acid methyl ester; 2-Pyridinecarboxylic acid, 4-(trifluoromethyl)-, methyl ester; Methyl 4-(trifluoromethyl)pyridine-2-carboxylate; 4-Trifluoromethyl-picolinic acid methyl ester; Picolinic acid, 4-(trifluoromethyl)-, methyl ester
EINECS	Contact for details

Quality Control

Our 2-Pyridinecarboxylic Acid, 4-(Trifluoromethyl)-, Methyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee traceability and consistency for your critical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Purity (HPLC, Area %)	≥ 99.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.