Description

2-Fluoropyridine-3-Boronic Acid Pinacol Ester is a high-value organoboron building block essential for modern synthetic chemistry. This compound is a key reagent in Suzuki-Miyaura cross-coupling reactions, enabling the efficient construction of complex biaryl and heterobiaryl structures. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and advanced material researchers for the synthesis of novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for fluorinated drug candidates targeting CNS disorders, oncology, and anti-infectives.
• Agrochemical Synthesis: Used to create novel fluorinated pyridine derivatives with potential herbicidal, fungicidal, or insecticidal activity.
• Material Science Research: Serves as a building block for constructing organic electronic materials, such as ligands for OLEDs or conductive polymers.
• Chemical Biology & Probe Development: Employed in the creation of molecular probes and tags for studying biological systems and diagnostic applications.
• Catalyst Ligand Synthesis: Useful for preparing sophisticated ligand systems in transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke synthesis projects and library production.

Basic Information

Product Name	2-Fluoropyridine-3-Boronic Acid Pinacol Ester
CAS No.	452972-14-4
Molecular Formula	C11H15BFNO2
Molecular Weight	223.05 g/mol
Synonyms	(2-Fluoropyridin-3-yl)boronic acid pinacol ester; 2-Fluoro-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; 3-Borono-2-fluoropyridine pinacol ester; 2-Fluoro-3-pyridineboronic acid pinacol ester; 2-Fluoro-3-(pinacolatoboryl)pyridine; 452972-14-4; Pinacol 2-fluoropyridine-3-boronate
EINECS	Contact for details

Quality Control

Our 2-Fluoropyridine-3-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and LC-MS, to ensure high purity and consistency. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for prolonged use or when opening the primary container to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.