Description

Gw788388 is a high-purity, small molecule compound identified by CAS NO 452342-67-5. This product is a critical research-grade chemical, valued for its role as a potent and selective inhibitor of the TGF-β type I receptor ALK5, which is central to numerous cellular signaling pathways. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in the study of fibrosis, oncology, and cellular differentiation processes.

Application

• Biomedical Research: A key tool compound for investigating the TGF-β/ALK5 signaling pathway in vitro and in vivo.
• Drug Discovery & Development: Used as a reference standard and pharmacological probe in preclinical studies for anti-fibrotic and anti-cancer therapeutic candidates.
• Cell Biology Studies: Employed to modulate cell proliferation, differentiation, and epithelial-mesenchymal transition (EMT) in various cell culture models.
• Target Validation: Serves to validate ALK5 as a therapeutic target in disease models related to tissue scarring and fibrosis.
• Academic Research: Facilitates fundamental research in developmental biology, immunology, and wound healing mechanisms.

Basic Information

Product Name	Gw788388
CAS No.	452342-67-5
Molecular Formula	C₂₂H₁₈N₄O₃
Molecular Weight	386.40 g/mol
Synonyms	ALK5 Inhibitor II; 2-[3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl]-1,5-naphthyridine; GW-788388; GW788388; TGF-β Receptor I Kinase Inhibitor IV; 3-(6-Methyl-2-pyridinyl)-N-phenyl-4-(4-quinolinyl)-1H-pyrazole-1-carbothioamide
EINECS	Contact for details

Quality Control

Our Gw788388 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is accompanied by comprehensive analytical data, including HPLC purity, NMR, and mass spectrometry for identity confirmation. Certificates of Analysis (COA) are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below for long-term stability. The compound is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.