Description

Alk5 Inhibitor Ii CAS NO 446859-33-2 is a potent and selective small molecule inhibitor of the ALK5 (TGF-β type I receptor) kinase. This compound is a critical research tool for investigating the TGF-β signaling pathway, which plays a fundamental role in cell proliferation, differentiation, and fibrosis. It is essential for researchers and developers in pharmaceutical R&D, biotechnology, and academic institutions focused on oncology, fibrotic diseases, and cell biology.

Application

• Biochemical Research: Used as a selective inhibitor to study TGF-β/ALK5-mediated signal transduction pathways in vitro.
• Drug Discovery & Development: Serves as a reference compound or lead molecule in the development of novel therapeutics targeting fibrosis and cancer.
• Cell Culture & Assay Development: Applied in cell-based assays to modulate TGF-β activity and study its effects on cell growth, differentiation, and epithelial-mesenchymal transition (EMT).
• Target Validation: Utilized to confirm the role of ALK5 kinase in specific disease models and biological processes.
• Academic Research: A key reagent for fundamental research in molecular biology, developmental biology, and immunology related to TGF-β signaling.

Basic Information

Product Name	Alk5 Inhibitor Ii
CAS No.	446859-33-2
Molecular Formula	C₂₂H₁₈N₄O₃
Molecular Weight	386.41 g/mol
Synonyms	ALK5 Inhibitor II; 2-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)-1,5-naphthyridine; LY-364947; LY364947; TGF-β Receptor I Kinase Inhibitor II; 4-[4-(1,3-Benzodioxol-5-yl)-5-(2-pyridinyl)-1H-imidazol-2-yl]benzamide; ALK5 Kinase Inhibitor
EINECS	Contact for details

Quality Control

Our Alk5 Inhibitor II is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and mass spectrometry, to ensure identity, potency, and consistency. A detailed Certificate of Analysis (COA) is provided with every shipment, confirming compliance with our stringent specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccant. The product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.