Description

Ikk Inhibitor Iii, Bms-345541 is a potent and selective small molecule inhibitor of the IκB kinase (IKK) complex, specifically targeting the IKK-2/IKKβ isoform. This compound is a critical research tool for modulating the NF-κB signaling pathway, which plays a central role in inflammation, immune response, and cell survival. It is primarily utilized by pharmaceutical researchers, medicinal chemists, and biologists in drug discovery programs and mechanistic studies focused on inflammatory diseases, autoimmune disorders, and oncology.

Application

• Biochemical Research: Used as a selective tool compound to inhibit IKK-2/IKKβ activity in in vitro kinase assays and cell-based studies.
• Drug Discovery & Development: Serves as a lead compound or reference standard in the development of novel anti-inflammatory and anti-cancer therapeutics targeting the NF-κB pathway.
• Inflammatory Disease Models: Applied in preclinical research to investigate the role of NF-κB signaling in conditions such as rheumatoid arthritis, asthma, and inflammatory bowel disease (IBD).
• Oncology Research: Employed to study the contribution of constitutive NF-κB activation to tumor cell proliferation, survival, and resistance to chemotherapy.
• Immunology Studies: Utilized to dissect the molecular mechanisms of immune cell activation and cytokine production.
• Academic & Institutional Research: A key reagent for universities and research institutes conducting fundamental research on signal transduction pathways.

Basic Information

Product Name	Ikk Inhibitor Iii, Bms-345541
CAS No.	445430-58-0
Molecular Formula	C₂₀H₂₁N₅O₂
Molecular Weight	363.42 g/mol
Synonyms	BMS-345541; 4(2'-Aminoethyl)amino-1,8-dimethylimidazo(1,2-a)quinoxaline; IKK Inhibitor III; IKK-2 Inhibitor IV; IKKβ Inhibitor BMS-345541; 4-[(2-Aminoethyl)amino]-1,8-dimethylimidazo[1,2-a]quinoxaline; NF-κB Activation Inhibitor IV; 1,8-Dimethyl-4-[(2-aminoethyl)amino]imidazo[1,2-a]quinoxaline
EINECS	Contact for details

Quality Control

Our Ikk Inhibitor Iii, Bms-345541 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) providing full characterization data, including purity by HPLC, identity confirmation (NMR, MS), and impurity profile. We adhere to rigorous analytical standards to support the integrity of your scientific research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under desiccated conditions. This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to maintain stability. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%
Solubility	Soluble in DMSO, DMF; slightly soluble in ethanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.