Description

4-Bromo-2-Difluoromethyl-1-Fluorobenzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. This compound is valued for its unique substitution pattern, which allows for selective functionalization and the introduction of fluorine atoms into complex molecular architectures. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for introducing fluorinated motifs to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the production of advanced pesticides and herbicides, where the fluorine atoms enhance biological activity and environmental persistence.
• Material Science Research: Serves as a precursor for the synthesis of fluorinated liquid crystals, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Buchwald-Hartwig amination for carbon-carbon and carbon-heteroatom bond formation.
• Fluorine Chemistry Exploration: Used in academic and industrial labs to study the effects of difluoromethyl and fluorine groups on aromatic system reactivity and electronic properties.
• Fine Chemical Production: Employed in the multi-step synthesis of complex fluorinated fine chemicals and specialty reagents.

Basic Information

Item	Detail
Product Name	4-Bromo-2-Difluoromethyl-1-Fluorobenzene
CAS No.	445303-69-5
Molecular Formula	C7H4BrF3
Molecular Weight	225.01 g/mol
Synonyms	1-Bromo-4-(difluoromethyl)-2-fluorobenzene; 2-Fluoro-α,α-difluoro-4-bromotoluene; 4-Bromo-2-(difluoromethyl)fluorobenzene; 2-Fluoro-4-bromobenzylidene difluoride; 4-Bromo-α,α-difluoro-2-fluorotoluene; 2-Fluorobenzyl bromide, α,α-difluoro-4-bromo-
EINECS	Contact for details

Quality Control

Our 4-Bromo-2-Difluoromethyl-1-Fluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our commitment to consistent quality and traceability supports your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. The container must be kept tightly closed to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow clear liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Individual impurity ≤ 0.5%, Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.