Description

16-Epi-Latrunculin B is a potent and specific marine-derived macrolide that acts as an actin polymerization inhibitor. This compound is a critical research tool for studying cytoskeletal dynamics, cell motility, and morphology in various biological systems. It is primarily utilized by researchers and scientists in the fields of cell biology, pharmacology, and drug discovery for in vitro applications.

Application

• Cytoskeleton Research: Used to disrupt actin filament networks, enabling studies on cell shape, adhesion, and migration.
• Cell Biology Assays: A key reagent for investigating the role of actin in processes like cytokinesis, endocytosis, and intracellular transport.
• Pharmacological Studies: Serves as a reference standard and tool compound for exploring pathways related to actin dynamics and their implications in disease.
• Drug Discovery Screening: Employed in high-throughput screening assays to identify novel compounds that modulate the actin cytoskeleton.
• Neuroscience Research: Applied in studies of neuronal growth cone dynamics and synaptic plasticity where actin remodeling is crucial.
• Oncology Research: Used to examine the role of actin in cancer cell invasion, metastasis, and resistance mechanisms.

Basic Information

Product Name	16-Epi-Latrunculin B
CAS No.	444911-05-1
Molecular Formula	C₂₂H₃₁NO₅S
Molecular Weight	421.55 g/mol
Synonyms	16-Epi-Latrunculin B; (4S,7R,8S,9S,16S,18E)-7,8-Epoxy-4,9-dihydroxy-2,16-dimethyl-13-oxo-1-oxacyclohexadeca-2,5,11,14,18-pentaene-6-carbothioic Acid N-Methylamide; Latrunculin B, 16-epi-; 16-epi-Lat B
EINECS	Contact for details

Quality Control

Our 16-Epi-Latrunculin B is produced under strict quality management protocols to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is accompanied by comprehensive analytical data, including HPLC, NMR, and MS. Certificates of Analysis (COA) are available upon request to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. Due to its hygroscopic nature, the container should be allowed to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.