Description

2-Fluoropyridine-5-Boronic Acid Pinacol Ester is a high-value, organoboron building block essential for modern synthetic chemistry, particularly in cross-coupling reactions. Its core value lies in enabling the precise construction of complex fluorinated heterocyclic scaffolds, which are critical motifs in advanced material and pharmaceutical research. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and material science industries for creating novel active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate: A key precursor in Suzuki-Miyaura cross-coupling reactions for synthesizing fluorinated pyridine derivatives, which are valuable scaffolds in drug discovery for oncology, CNS, and anti-infective therapies.
• Agrochemical Synthesis: Used to incorporate the 2-fluoropyridine moiety into novel herbicides, fungicides, and insecticides, enhancing their biological activity and environmental profile.
• Material Science Research: Serves as a building block for creating fluorinated organic semiconductors, liquid crystals, and metal-organic frameworks (MOFs) with tailored electronic and optical properties.
• Chemical Biology & Probe Development: Employed in the synthesis of fluorinated molecular probes and tags for studying biological processes and diagnostic applications.
• Custom Synthesis & Contract Manufacturing: Supplied to CROs and CDMOs for the development and scale-up of proprietary compounds for clients.

Basic Information

Product Name	2-Fluoropyridine-5-Boronic Acid Pinacol Ester
CAS No.	444120-95-0
Molecular Formula	C11H15BFNO2
Molecular Weight	223.06 g/mol
Synonyms	5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-2-fluoropyridine; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; (2-Fluoropyridin-5-yl)boronic acid pinacol ester; 2-Fluoro-5-pyridineboronic acid pinacol ester; 2-Fluoro-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine; Pinacol 2-Fluoropyridine-5-boronate
EINECS	Contact for details

Quality Control

Our 2-Fluoropyridine-5-Boronic Acid Pinacol Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for sensitive cross-coupling applications. Certificates of Analysis (COA) with detailed specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and when dispensing to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.