Description

Cdk1/2 Inhibitor Iii CAS NO 443798-47-8 is a potent and selective small molecule inhibitor of cyclin-dependent kinases 1 and 2 (CDK1/2), key regulators of the cell cycle. This compound is a critical research tool for investigating cell cycle progression, DNA damage response, and the mechanisms of oncogenesis in various cancer models. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on oncology, molecular biology, and drug discovery.

Application

• Biochemical Research: Used as a selective inhibitor to study the specific roles and signaling pathways of CDK1 and CDK2 in vitro.
• Cell Biology Studies: Applied in cell culture experiments to induce cell cycle arrest, particularly at the G1/S and G2/M checkpoints, for functional analysis.
• Oncology & Cancer Research: Serves as a key pharmacological probe to validate CDK1/2 as therapeutic targets and to explore combination therapies in cancer cell lines and xenograft models.
• Drug Discovery & Development: Employed as a reference compound or positive control in high-throughput screening (HTS) assays and lead optimization programs for novel CDK inhibitors.
• Mechanistic Studies: Facilitates the investigation of transcription, apoptosis, and DNA repair mechanisms linked to CDK activity.

Basic Information

Product Name	Cdk1/2 Inhibitor Iii
CAS No.	443798-47-8
Molecular Formula	C₁₆H₁₈N₈O
Molecular Weight	338.37 g/mol
Synonyms	CDK1/2 Inhibitor III; 2-((2-Pyridinylmethylene)amino)-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide; 2-[(Pyridin-2-ylmethylidene)amino]-N-(1H-pyrazolo[3,4-b]pyridin-3-yl)acetamide; BML-259; CAS 443798-47-8; CDK Inhibitor III; CDK1 Inhibitor III
EINECS	Contact for details

Quality Control

Our Cdk1/2 Inhibitor Iii is manufactured under strict quality protocols to ensure batch-to-batch consistency and high biological activity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and identity confirmation. A Certificate of Analysis (COA) detailing purity, potency, and analytical results is provided with every shipment to support your research integrity and documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert conditions for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation. For short-term use, store in a cool, dry place (2-8°C).

Specification

Item	Specification
Appearance	Off-white to light yellow solid
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; Slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.