Description

2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is a high-value, multi-functional boronic ester building block essential for modern synthetic chemistry. Its core value lies in enabling precise carbon-carbon bond formation via Suzuki-Miyaura cross-coupling reactions, a cornerstone of pharmaceutical and advanced materials development. This compound is critically needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and organic electronics industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs) and drug candidates, particularly in fluorinated compound libraries.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides that require specific fluorinated aromatic structures.
• Material Science & OLED Development: Serves as a precursor for creating advanced organic light-emitting diode (OLED) materials and other functional polymers where the aldehyde and boronate groups allow for further functionalization.
• Cross-Coupling Reactions: Primarily employed in palladium-catalyzed Suzuki-Miyaura cross-coupling to introduce the 2-fluoro-5-formylphenyl moiety into target molecules with high efficiency and selectivity.
• Ligand and Catalyst Design: Useful in the synthesis of specialized ligands for catalysis and metal-organic frameworks (MOFs).
• Chemical Research & Development: A versatile reagent for academic and industrial research in synthetic organic chemistry, enabling the exploration of new chemical spaces.

Basic Information

Item	Details
Product Name	2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde
CAS No.	443776-94-1
Molecular Formula	C13H16BFO3
Molecular Weight	250.08 g/mol
Synonyms	2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde; 5-Formyl-2-fluorophenylboronic acid pinacol ester; (5-Formyl-2-fluorophenyl)boronic acid pinacol ester; 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenecarboxaldehyde; Benzaldehyde, 2-fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-; 443776-94-1; 2-Fluoro-5-formylphenylboronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our 2-Fluoro-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high purity and consistent performance in sensitive cross-coupling applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place at 2-8°C to minimize degradation due to its hygroscopic and easily oxidized nature. Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥97.0%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.