Description

Glucagon Receptor Antagonist I is a potent and selective small-molecule inhibitor of the glucagon receptor, a key target in metabolic research. This compound is crucial for investigating the role of glucagon signaling in glucose homeostasis and for the preclinical development of novel therapeutics for type 2 diabetes and related metabolic disorders. It is an essential research tool for pharmaceutical R&D teams, academic institutions, and biotechnology companies focused on endocrinology and metabolic disease pathways.

Application

• Pharmacological Research: Used as a reference standard and tool compound in in vitro and in vivo studies to elucidate glucagon receptor function and signaling mechanisms.
• Drug Discovery & Development: Serves as a critical lead compound or benchmark in high-throughput screening (HTS) campaigns and structure-activity relationship (SAR) studies for anti-diabetic agents.
• Metabolic Disease Modeling: Applied in animal models to study the effects of glucagon receptor antagonism on hyperglycemia, hepatic glucose production, and lipid metabolism.
• Biochemical Assay Development: Utilized to validate and optimize cell-based reporter assays and receptor binding assays targeting the glucagon receptor.
• Academic & Institutional Research: Supports fundamental research in university and hospital laboratories exploring endocrine regulation and novel therapeutic targets for obesity and diabetes.

Basic Information

Product Name	Glucagon Receptor Antagonist I
CAS No.	438618-32-7
Molecular Formula	C₂₃H₂₅ClN₄O₃
Molecular Weight	440.92 g/mol
Synonyms	N-[4-(1H-Benzimidazol-2-ylmethylamino)benzoyl]-β-alanine; BAY 27-9955; 3-[4-[(1H-Benzimidazol-2-ylmethyl)amino]benzoyl]amino]propanoic acid; Glucagon Receptor Antagonist; GCGR Antagonist I; (3-{4-[(1H-Benzimidazol-2-ylmethyl)amino]benzoylamino}propionic acid)
EINECS	Contact for details

Quality Control

Every batch of Glucagon Receptor Antagonist I is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to ensure identity, purity, and consistency for research applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting results from advanced techniques including HPLC, NMR, and mass spectrometry.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under inert atmosphere for long-term stability. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥98.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.