Description

3-Bromo-5-(trifluoromethyl)pyridine is a high-purity, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique molecular structure, featuring both bromine and trifluoromethyl substituents, makes it an exceptionally versatile intermediate for introducing specific functionalities into target molecules. This compound is primarily utilized by research and development chemists and process engineers in the pharmaceutical and agrochemical industries for creating novel active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing properties of the trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of functionalized polymers, liquid crystals, and electronic materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions due to the reactive bromine atom.
• Chemical Biology Probes: Used to create molecular probes for studying biological systems and protein interactions.

Basic Information

Product Name	3-Bromo-5-(trifluoromethyl)pyridine
CAS No.	436799-33-6
Molecular Formula	C6H3BrF3N
Molecular Weight	225.99 g/mol
Synonyms	5-(Trifluoromethyl)-3-bromopyridine; 3-Bromo-5-(trifluoromethyl)pyridine; 3-Bromo-5-trifluoromethylpyridine; Pyridine, 3-bromo-5-(trifluoromethyl)-; 3-Bromo-5-(trifluoromethyl)pyridine, 98+%; 436799-33-6; 3-Br-5-CF3-Py
EINECS	Contact for details

Quality Control

Every batch of 3-Bromo-5-(trifluoromethyl)pyridine is manufactured and tested under a strict quality management system. Our products undergo rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high purity and consistent lot-to-lot quality suitable for demanding synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.