Description

2-Trifluoromethyl-5-Bromopyridine is a high-value, multi-functional halogenated pyridine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both bromine and a trifluoromethyl group on the pyridine ring, makes it indispensable for introducing these pharmacophores into target molecules. This compound is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand & Catalyst Development: Serves as a versatile scaffold for constructing complex ligands used in transition metal catalysis and organocatalysis.
• Material Science Research: Employed in the synthesis of specialty polymers, liquid crystals, and electronic materials that require fluorinated aromatic components.
• Cross-Coupling Reactions: The bromine substituent makes it an excellent substrate for Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Functional Group Transformation: Used in nucleophilic substitution reactions to introduce amines, alkoxides, and other functionalities at the 5-position.

Basic Information

Product Name	2-Trifluoromethyl-5-Bromopyridine
CAS No.	436799-32-5
Molecular Formula	C6H3BrF3N
Molecular Weight	225.99 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)pyridine; 5-Bromo-α,α,α-trifluoro-2-picoline; 2-Pyridinecarbonitrile, 5-bromo-α,α,α-trifluoro-; 5-Bromo-2-trifluoromethylpyridine; 2-Trifluoromethyl-5-bromopyridine; 5-Bromo-2-(trifluoromethyl)pyridine; 5-Bromo-α,α,α-trifluoro-2-picoline; 2-(Trifluoromethyl)-5-bromopyridine
EINECS	Contact for details

Quality Control

Every batch of 2-Trifluoromethyl-5-Bromopyridine is manufactured and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the high-purity standards required for research and scale-up applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, documenting identity, purity, and impurity profiles as determined by GC, HPLC, NMR, and other relevant techniques.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Purity (GC)	≥ 97.5%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.