Description

(+/-)-15-Deoxy-16R-Hydroxy-17-Cyclobutyl Prostaglandin E1 CAS NO 433219-55-7 is a synthetic prostaglandin E1 (PGE1) analogue, a key intermediate in the development of advanced pharmaceutical compounds. This molecule is valued for its structural modifications, which enhance stability and target specificity compared to native prostaglandins. It is primarily utilized by pharmaceutical R&D and manufacturing organizations for the synthesis of novel therapeutic agents targeting cardiovascular, ocular, and inflammatory pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel prostaglandin-based drugs.
• Cardiovascular Research: Used in preclinical studies for developing vasodilatory and anti-thrombotic agents.
• Ophthalmic Drug Development: Serves as a precursor for intraocular pressure-lowering medications (anti-glaucoma drugs).
• Inflammation & Immunology Studies: Employed in research to modulate inflammatory pathways and immune responses.
• Chemical Biology Probes: Utilized as a tool compound to study prostaglandin receptor (EP receptor) signaling and function.
• Process Chemistry & Scale-up: Serves as a key intermediate for process optimization and commercial-scale API (Active Pharmaceutical Ingredient) manufacturing.

Basic Information

Product Name	(+/-)-15-Deoxy-16R-Hydroxy-17-Cyclobutyl Prostaglandin E1
CAS No.	433219-55-7
Molecular Formula	C₂₄H₃₈O₅
Molecular Weight	406.56 g/mol
Synonyms	15-Deoxy-16R-hydroxy-17-cyclobutyl PGE1; 17-Cyclobutyl-15-deoxy-16R-hydroxyprostaglandin E1; 15-Deoxy-16R-hydroxy-17-cyclobutyl-prostaglandin E1; PGE1 Cyclobutyl Analogue; Prostaglandin E1 Derivative; 433219-55-7; 15-Deoxy-16-hydroxy-17-cyclobutyl PGE1 (racemic)
EINECS	Contact for details

Quality Control

Our (+/-)-15-Deoxy-16R-Hydroxy-17-Cyclobutyl Prostaglandin E1 is manufactured under strict quality systems to ensure high purity and batch-to-batch consistency, suitable for demanding research and development applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We support compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. For long-term storage, desiccate to maintain stability. Allow the sealed container to reach room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.