Description

Skp2 Inhibitor C1 is a potent and selective small molecule inhibitor of the S-phase kinase-associated protein 2 (Skp2), a key component of the Skp1-Cul1-F-box (SCF) ubiquitin ligase complex. This compound matters as a critical research tool for investigating cell cycle regulation, protein degradation pathways, and oncogenesis, offering significant value in the study of cancers where Skp2 is often overexpressed. It is primarily needed by researchers and pharmaceutical developers in the fields of oncology, molecular biology, and drug discovery for in vitro and in vivo studies.

Application

• Biomedical Research: Used as a selective chemical probe to study the role of the Skp2-p27 axis in cell cycle progression and cellular senescence.
• Oncology Studies: Investigated for its potential to inhibit tumor growth and proliferation in various cancer models, particularly those dependent on Skp2 activity.
• Mechanistic Biology: Essential for elucidating the SCF ubiquitin ligase pathway and its impact on the degradation of cell cycle regulators like p27, p21, and p57.
• Drug Discovery & Development: Serves as a lead compound or reference standard in high-throughput screening and structure-activity relationship (SAR) studies for novel anticancer agents.
• Academic Research: Employed in university and institutional labs for fundamental research into protein turnover, signal transduction, and cancer biology.

Basic Information

Product Name	Skp2 Inhibitor C1
CAS No.	432001-69-9
Molecular Formula	C₂₀H₂₀N₄O₂S
Molecular Weight	380.46 g/mol
Synonyms	Skp2 Inhibitor C1; C1 Skp2 Inhibitor; 6-(4-tert-Butylphenyl)-3-[(3-nitrophenyl)thio]-1,2,4-triazolo[3,4-b][1,3,4]thiadiazole; 6-(4-(tert-Butyl)phenyl)-3-((3-nitrophenyl)thio)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazole; SZL P1-41; SZL-P1-41; P1-41; Skp2-p27 Inhibitor; SCF-Skp2 Inhibitor
EINECS	Contact for details

Quality Control

Our Skp2 Inhibitor C1 is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. Certificates of Analysis (COA) detailing all specifications and test results are available upon request to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	Yellow to light brown solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass Spectrometry)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.