Description

Iwr-1/Iwr1 is a potent and selective small molecule inhibitor of the Wnt/β-catenin signaling pathway, identified by CAS number 430429-02-0. This compound is a critical research tool for studying cellular processes related to development, stem cell regulation, and oncogenesis, offering high specificity for targeted biological studies. It is primarily utilized by pharmaceutical R&D teams, academic researchers, and biotechnology companies engaged in drug discovery and molecular biology.

Application

• Wnt Pathway Research: A key reagent for fundamental research into the Wnt/β-catenin signaling cascade and its role in development and disease.
• Oncology Studies: Used to investigate and validate the Wnt pathway as a therapeutic target in various cancers, including colorectal, breast, and liver cancer models.
• Stem Cell Biology: Employed to modulate Wnt signaling to control stem cell self-renewal, differentiation, and pluripotency in vitro.
• Drug Discovery & Screening: Serves as a reference standard and pharmacological tool in high-throughput screening assays and lead optimization programs.
• Bone Metabolism Research: Applied in studies exploring the role of Wnt signaling in bone formation, homeostasis, and related disorders.
• Biochemical Assay Development: Used as a control compound to develop and validate cell-based and biochemical assays targeting the Wnt pathway.

Basic Information

Product Name	Iwr-1/Iwr1
CAS No.	430429-02-0
Molecular Formula	C₁₉H₁₄N₄O₂
Molecular Weight	330.34 g/mol
Synonyms	IWR-1; IWR 1; IWR1; 4-(1,3,4-Oxadiazol-2-yl)phenyl-4-(pyridin-2-yl)piperazine-1-carboxylate; 1-(4-(1,3,4-Oxadiazol-2-yl)phenyl)-3-(4-(pyridin-2-yl)piperazin-1-yl)propan-1-one; Wnt/β-catenin pathway inhibitor IWR-1; Inhibitor of Wnt Response 1; Endo-IWR-1
EINECS	Contact for details

Quality Control

Our Iwr-1/Iwr1 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and NMR/LC-MS for structural confirmation, to ensure identity, potency, and consistency. Certificates of Analysis (COA) with detailed chromatographic data are provided to support your research and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, cool place. This product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (Mass)	Conforms (M+1: 331.1)
Purity (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.