Description

Cathepsin G Inhibitor I is a potent and selective small-molecule inhibitor of the serine protease Cathepsin G. This compound is a critical research tool for investigating the role of Cathepsin G in inflammatory processes, immune cell signaling, and disease pathology. It is primarily utilized by researchers and scientists in the fields of pharmaceutical R&D, biochemistry, and immunology for target validation and mechanistic studies.

Application

• Biochemical Research: Used as a selective tool compound to study the enzymatic activity and biological function of Cathepsin G in vitro.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of novel anti-inflammatory and immunomodulatory therapeutics.
• Inflammation Studies: Applied in cellular and animal models to elucidate the role of Cathepsin G in neutrophil-mediated inflammation and tissue damage.
• Protease Profiling: Employed in selectivity panels to assess off-target effects against other serine proteases, ensuring research specificity.
• Academic Research: A key reagent for universities and research institutes exploring protease biology, signaling pathways, and related disease mechanisms.

Basic Information

Product Name	Cathepsin G Inhibitor I
CAS No.	429676-93-7
Molecular Formula	C21H21N3O4S
Molecular Weight	411.48 g/mol
Synonyms	N-[[(1S)-1-[[(3S,3aS,6aR)-Hexahydro-1,3-dioxo-1H-furo[3,4-c]pyrrol-3a(3H)-yl]carbonyl]-3-methylbutyl]amino]carbonyl]-4-methyl-benzenesulfonamide; Benzenesulfonamide, N-[[[(1S)-1-[[(3S,3aS,6aR)-hexahydro-1,3-dioxo-1H-furo[3,4-c]pyrrol-3a(3H)-yl]carbonyl]-3-methylbutyl]amino]carbonyl]-4-methyl-; Cathepsin G Inhibitor; Z-Gly-Leu-Phe-chloromethyl ketone (alternative class representative); CG Inhibitor I
EINECS	Contact for details

Quality Control

Our Cathepsin G Inhibitor I is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and functional activity assays to ensure biological potency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment to guarantee reproducibility and reliability for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to warm to room temperature in a desiccator before opening to prevent condensation and hydrolysis.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Solubility	Soluble in DMSO, DMF; sparingly soluble in aqueous buffers
Biological Activity (IC50)	≤ 50 nM (vs. Human Cathepsin G)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.