Description

α-Cyclodextrin, 6A,6B,6C,6D,6E,6F-Hexakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F-Hexathio-, Sodium Salt (1:6) is a chemically modified, water-soluble derivative of α-cyclodextrin featuring six thioether-linked carboxyethyl arms, each terminated as a sodium carboxylate. This unique structure provides enhanced molecular encapsulation capabilities and introduces multiple anionic binding sites, making it a powerful tool for complexation and solubilization. It is essential for researchers and formulators in advanced pharmaceutical development, nanotechnology, and specialty chemical synthesis who require precise host-guest chemistry and improved aqueous solubility of hydrophobic compounds.

Application

• Pharmaceutical Research & Drug Delivery: Acts as a sophisticated solubilizing and stabilizing agent for poorly water-soluble active pharmaceutical ingredients (APIs), enhancing bioavailability and enabling novel formulation strategies.
• Nanomaterial & Supramolecular Chemistry: Serves as a functional building block or template for constructing complex molecular architectures, sensors, and drug delivery vehicles due to its multiple anionic charges and cavity.
• Catalysis: Used to create modified catalytic systems where the cyclodextrin cavity provides a selective microenvironment for reactions, with the carboxylate groups enabling immobilization or further functionalization.
• Analytical Chemistry & Separation Science: Employed as a chiral selector or a stationary phase modifier in capillary electrophoresis (CE) and chromatography for the separation of enantiomers and isomers.
• Cosmetic & Personal Care Formulations: Enhances the stability and delivery of active ingredients in skincare products, such as vitamins and fragrances, by forming inclusion complexes.
• Chemical Synthesis Intermediate: Provides a versatile platform for further synthetic modifications, allowing the creation of custom-designed cyclodextrin derivatives with tailored properties.

Basic Information

Item	Details
Product Name	α-Cyclodextrin, 6A,6B,6C,6D,6E,6F-Hexakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F-Hexathio-, Sodium Salt (1:6)
CAS No.	426267-20-1
Molecular Formula	C54H78Na6O30S6
Molecular Weight	~1561.5 g/mol
Synonyms	6-Per-S-carboxyethylthio-α-cyclodextrin sodium salt; Hexakis(2-carboxyethylthio)-α-cyclodextrin sodium salt; α-CD-SC2H4COONa; Sodium 6A,6B,6C,6D,6E,6F-hexakis(2-carboxyethylthio)-6A,6B,6C,6D,6E,6F-hexadeoxy-α-cyclodextrin; Water-soluble thiolated α-cyclodextrin derivative; Anionic α-cyclodextrin polymer precursor
EINECS	Contact for details

Quality Control

Our α-Cyclodextrin, 6A,6B,6C,6D,6E,6F-Hexakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F-Hexathio-, Sodium Salt (1:6) is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including NMR, HPLC, and elemental analysis, to confirm structural identity, purity, and substitution degree. Certificates of Analysis (COA) detailing batch-specific results are provided and available upon request to support your research and quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive). To prevent degradation and clumping, the container must be kept tightly sealed in a dry environment. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals (as Pb)	≤ 20 ppm
Degree of Substitution (NMR)	5.8 - 6.2

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.