Description

6-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One is a high-value, heterocyclic organic compound featuring a fused triazolopyridine core substituted with a trifluoromethyl group. This structure is of significant interest for its role as a versatile advanced pharmaceutical intermediate and a key building block in medicinal chemistry. It is primarily sought after by R&D and production teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical building block for the research and synthesis of new drug candidates, particularly in therapeutic areas targeting the central nervous system, inflammation, and oncology.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, leveraging the biological activity of the triazolopyridine scaffold.
• Medicinal Chemistry Research: Serves as a core scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Chemical Biology Probes: Utilized in the creation of specialized probes and ligands for studying biological pathways and target validation.
• Material Science Research: Investigated as a precursor for the synthesis of specialty chemicals and functional materials with unique electronic properties.

Basic Information

Product Name	6-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One
CAS No.	425702-95-0
Molecular Formula	C7H4F3N3O
Molecular Weight	203.12 g/mol
Synonyms	6-(Trifluoromethyl)-2H-[1,2,4]triazolo[4,3-a]pyridin-3-one; 6-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one; 425702-95-0; 6-Trifluoromethyl-[1,2,4]triazolo[4,3-a]pyridin-3(2H)-one; 6-Trifluoromethyl-1,2,4-triazolo[4,3-a]pyridin-3(2H)-one; 6-(Trifluoromethyl)-1,2,4-triazolo[4,3-a]pyridin-3-ol (tautomer); TFP-OH (common abbreviation)
EINECS	Contact for details

Quality Control

Our 6-(Trifluoromethyl)-[1,2,4]Triazolo[4,3-A]Pyridin-3(2H)-One is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications and industry best practices for advanced intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.